This paper develops a computational model for nonlinear bending analysis of functionally graded (FG) plates using a four-node quadrilateral element SQ4T within the context of the first order shear deformation theory (FSDT). In particular, the construction of the nonlinear geometric equations are based on Total Lagrangian approach in which the motion at the present state compared with the initia...

This paper is a review of methods and techniques used for precise measurement of time intervals (TIs) or precise conversion of TIs to digital data. The following methods are described: the counter method and averaging, time stretching, time-to-amplitude conversion followed by analogue-to-digital conversion, the Vernier method, conversion utilizing tapped delay lines, and interpolation methods. ...

Repeated bouts of acute and chronic lung infections are responsible for progressive pulmonary function decline in individuals with cystic fibrosis (CF), ultimately leading to respiratory failure and death. Pseudomonas aeruginosa is the archetypical CF pathogen, causes chronic infection in 70% of individuals, and is associated with an accelerated clinical decline. The management of P. aeruginosa...

We report the clinical trial studies for the ThinPrep Imaging System (TIS; Cytyc, Boxborough, MA). Between December 2000 and July 2001, 10,742 ThinPrep specimens were collected at 4 US clinical sites representative of the normal clinical population of the laboratories, including screening patients and referred patients. After nonstudy screening diagnoses were completed, the vials were relabeled...

The identification of translation initiation sites (TISs) constitutes an important aspect of sequence-based genome analysis. An erroneous TIS annotation can impair the identification of regulatory elements and N-terminal signal peptides, and also may flaw the determination of descent, for any particular gene. We have formulated a reference-free method to score the TIS annotation quality. The me...

PURPOSE To assess efficacy and safety of a new dry powder formulation of inhaled colistimethate sodium in patients with cystic fibrosis (CF) aged ≥6 years with chronic Pseudomonas aeruginosa lung infection. STUDY DESIGN AND METHODS A prospective, centrally randomised, phase III, open-label study in patients with stable CF aged ≥6 years with chronic P aeruginosa lung infection. Patients were r...

We measured size-resolved PNCs in the 5-560 nm range at two different types (4- and 3-way) of TIs in Guildford (Surrey, UK) at fixed sites (∼1.5 m above the road level), sequentially at 4 different heights (1, 1.5, 2.5 and 4.7 m), and along the road at five different distances (10, 20, 30, 45 and 60 m). The aims were to: (i) assess the differences in PNCs measured at studied TIs, (ii) identify ...

We present a multiterminal nanostructure for electrical probing of the quantum spin Hall effect QSHE in two-dimensional 2D topological insulators TIs . The device consists of a ferromagnetic FM island with precessing magnetization that pumps in the absence of any bias voltage pure spin current symmetrically into the left and right adjacent 2D TIs modeled as graphene nanoribbons with the intrins...

SUMMARY We proposed a tool named MetaTISA with an aim to improve TIS prediction of current gene-finders for metagenomes. The method employs a two-step strategy to predict translation initiation sites (TISs) by first clustering metagenomic fragments into phylogenetic groups and then predicting TISs independently for each group in an unsupervised manner. As evaluated on experimentally verified TI...