It is well known that Arginine-Glycine-Aspartic acid (RGD) and Asparagine-Glycine-Arginine (NGR) peptides preferentially bind to integrin receptors and aminopeptidase Nrespectively and these two receptors play important roles in angiogenesis. Therefore ketoprofenas a non-selective cox Inhibitor was conjugated with linear RGD and NGR to take advantageof targeting capability of these two motifs a...

It is well known that Arginine-Glycine-Aspartic acid (RGD) and Asparagine-Glycine-Arginine (NGR) peptides preferentially bind to integrin receptors and aminopeptidase Nrespectively and these two receptors play important roles in angiogenesis. Therefore ketoprofenas a non-selective cox Inhibitor was conjugated with linear RGD and NGR to take advantageof targeting capability of these two motifs a...

PROGRESSION MODEL 2 3 Michael S. Nastasie, Helmut Thissen, David A. Jans and Kylie M. Wagstaff 4 Nuclear Signalling Laboratory, Dept. Biochemistry and Molecular Biology, Monash 5 University, Clayton, Victoria 3800, Australia 6 CSIRO Molecular and Health Technologies, Bayview Avenue, Clayton, Victoria 3168, 7 Australia 8 Running Title: Tumour selective nuclear targeting 9 10 *Correspondence shou...

Tetrazine-functionalised boron-rich carbon dots show fast clearance and enhanced tumour accumulation under pre-targeting conditions, as demonstrated using positron emission tomography.

Transcriptional targeting is the best approach for specific gene therapy. Hypoxia is a common feature of the tumour microenvironment. Therefore, targeting gene expression in hypoxic cells by placing transgene under the control of a hypoxia-responsive promoter can be a good strategy for cancer-specific gene therapy. The hypoxia-inducible gene expression system has been investigated more in suici...

manipulations can be conducted at any desired time during an experiment. This novel approach to hydrogel design should be particularly appealing for fields such as developmental biology, stem-cell biology or tumour-cell biology, in which the role of the microenvironment in controlling cell function is particularly important and is still relatively poorly understood. With these novel ECM models ...