During the last decades, new radionuclide-based targeted therapies have emerged as efficient tools for cancer treatment. Targeted radionuclide therapies (TRTs) are based on a multidisciplinary approach that involves the cooperation of specialists in several research fields. Among them, radiobiologists investigate the biological effects of ionizing radiation, specifically the molecular and cellu...

From the *Leuhaemia Research Fund Centre, Institute of Cancer Research, London SW3 6JB; the eMRC Radiobiology Unit, Didcot 0XI10Rs United Kingdom; the $Oncogene and Tumor Suppressor Gene Program, La Jolla Cancer Research Foundation, La Jolla, California 92037; and the IIDepartment of Medicine, Microbiology and Immunology, Howard Hughes Medical Institute, Washington University School of Medicine...

Traditional factors of DNA damage and tumor cell kill, described by the "4 R's" of radiobiology (Reassortment, Reoxygenation, Repair, and Repopulation) fall short in explaining the role of immunity in hosts treated with radiotherapy. We propose a "5th R," (immune-mediated) Rejection, which recognizes the contribution of the immune system to the antineoplastic effects of radiotherapy.

From the *Leuhaemia Research Fund Centre, Institute of Cancer Research, London SW3 6JB; the eMRC Radiobiology Unit, Didcot 0XI10Rs United Kingdom; the $Oncogene and Tumor Suppressor Gene Program, La Jolla Cancer Research Foundation, La Jolla, California 92037; and the IIDepartment of Medicine, Microbiology and Immunology, Howard Hughes Medical Institute, Washington University School of Medicine...

A new variant of CLT is established for random elds de ned on Rd which are strictly stationary, with nite second moment and weakly dependent (comprising cases of positive or negative association). The summation domains grow in the van Hove sense. Simultaneously the indices of observations form more and more dense grids in these domains. Thus the e ect of combining two scaling procedures is stud...

The radiation killing of tumor cells by ionizing radiation is best described by the linear-quadratic (LQ) model. Research into the underlying mechanisms of α- and β-inactivation has suggested that different molecular targets (DNA in different forms) and different microdosimetric energy deposits (spurs versus electron track-ends) are involved. Clinical protocols with fractionated doses of about ...

Investigation of the mechanisms of radiation-induced brain injury is a relevant fundamental objective of radiobiology and neuroradiology. Damage to the healthy brain tissue is the key factor limiting the application of radiation therapy in patients with nervous systems neoplasms. Furthermore, postradiation brain injury can be clinically indiscernible from continued tumor growth and requires dif...

Personalized radiation treatment is an important goal in oncology. As a result, one of the main challenges radiobiology today predicting patient?s tissue radiosensitivity so that personalized can be tailored to individual. For first time since 2016, group from Institute Oncology and Radiology Serbia has begun performing translational research field radiobiology. The aim these studies identify m...

Alpha-particle emitter labeled monoclonal antibodies are being actively developed for treatment of metastatic cancer due to the high linear energy transfer (LET) and the resulting greater biological efficacy of alpha-emitters. Our knowledge of high LET particle radiobiology derives primarily from accelerated heavy ion beam studies. In heavy ion beam therapy of loco-regional tumors, the modulati...