introduction: angiogenesis, the process of new blood vessel formation from pre-existing vessels, has important physiological roles in embryonic development, female reproduction cycle, and wound healing. it is also crucial for pathological processes in several diseases especially tumor growth and metastasis. thereby, inhibition of angiogenesis as an addition to the conventional therapies such as...

basal cell carcinoma (bcc) is currently the most common cutaneous cancer found in humans. although it generally shows a relatively benign course (bccl), some cases show aggressive behavior (bcc2). until recently, traditional histologic diagnostic criteria have failed to discriminate unequivocally between bcc 1 and bcc2. in this study we selected 50 cases of bcc and categorized them into two gro...

angiogenesis, the process of new blood vessel formation from existing ones, plays an important role in  the physiologic circumstances such as embryonic development, placenta formation, and wound healing. it is also crucial to progress of pathogenic processes of a variety of disorders, including tumor growth and metastasis. in general, angiogenesis process is a multi-factorial and highly structu...

the basic pathogenic step in the process of tumor growth, invasion and metastasis is tumor-induced angiogenesis. the aim of this study was to evaluate the angiogenesis in colorectal carcinoma by microvascular density (mvd) determination with ihc (immunohistochemistry) method and to determine if and how angiogenesis correlates with clinicopathologic parameters. sixty two archival, paraffin embed...

Background: Angiogenesis initiated by cancerous cells is the process by which new blood vessels are formed to enhance oxygenation and growth of tumor. Objective: In this paper, we present a new multiscale mathematical model for the formation of a vascular network in tumor angiogenesis process. Methods: Our model couples an improved sprout spacing model as a stochastic mathematical model of spro...

tumor cells are dependent on angiogenesis to obtain oxygen and nutrients and also development of their new vascular network. vegf as an important stimulator of angiogenesis and endostatin as an inhibitor play a fundamental role in this process. this study was designed to investigate the effect of six weeks of resistance training on tumor tissue vegf andendostatin in mice with breast cancer. for...

exosomes, as a mediator of cell-to-cell transfer of genetic information, act an important role in intercommunication between tumor cells and their niche including fibroblasts, endothelial cells, adipocytes and monocytes. several studies have shown that tumor cells can influence their neighboring cells by releasing exosomes. these exosomes provide signaling cues for stimulation, activation, prol...

introduction as a tumor grows, the demand for oxygen and nutrients increases and it grows further if acquires the ability to induce angiogenesis. in this study, we aimed to present a two-dimensional continuous mathematical model for avascular tumor growth, coupled with a discrete model of angiogenesis. materials and methods in the avascular growth model, tumor is considered as a single mass, wh...

Introduction As a tumor grows, the demand for oxygen and nutrients increases and it grows further if acquires the ability to induce angiogenesis. In this study, we aimed to present a two-dimensional continuous mathematical model for avascular tumor growth, coupled with a discrete model of angiogenesis. Materials and Methods In the avascular growth model, tumor is considered as a single mass, wh...

tumor angiogenesis shown by microvessel count (mvc) or microvessel density (mvd), is assessed by several studies as prognostic factor in some types of tumors, and also in colorectal carcinoma. this article is payed to correlation between clincopathologic factors and tumor angiogenesis. in this study, immunohistochemical techniques are used for vascular evaluation in specimens from twenty-nine c...