نتایج جستجو برای: Trolox

تعداد نتایج: 1367  

Farzaneh Ketabchi, Seyed Mostafa Shid Moosavi Somayh Mansoori

Background: The mechanism of hypoxic pulmonary vasoconstriction (HPV) is still debatable. It has been proposed that reactive oxygen species (ROS) might be involved in HPV. However, there is no special transporter for superoxide anion in the cell membrane and it may release from the cells via anion exchanger. Therefore, the aim of this study was to investigate the interaction of ROS and anion ex...

Journal: :iranian journal of medical sciences 0
sara keshtgar department of physiology, school of medicine, shiraz university of medical sciences, shiraz, iran farideh iravanpour student research committee, shiraz university of medical sciences, shiraz, iran behrooz gharesi-fard department of immunology, school of medicine, shiraz university of medical sciences, shiraz, iran; infertility research center, shiraz university of medical sciences, shiraz, iran marjaneh kazerooni shiraz infertility center, shiraz, iran

the freezing and thawing process not only is associated with serious damage to sperm such as damage to the plasma membrane and the acrosomal membrane but also changes the membrane permeability to some ions including calcium. also, the generation of oxygen free radicals is increased during the freezing-thawing process. the purpose of this study was to evaluate of the effects of trolox as an anti...

Journal: :Journal of lipid research 1997
A R Bergmann P Ramos H Esterbauer B M Winklhofer-Roob

LDL resistance to oxidation is characterized by the lag time that precedes the rapid generation of conjugated dienes in copper-induced oxidation. Lag time (y) is described by the equation y = kx + a, where k is the efficacy constant of alpha-tocopherol (alpha-TOH), x the alpha-TOH content of LDL, and a the alpha-TOH-independent variable, all of which show considerable between-subject variabilit...

Journal: :Blood 2005
Zuanel Diaz Myrian Colombo Koren K Mann Haixiang Su Kamilah N Smith D Scott Bohle Hyman M Schipper Wilson H Miller

Although arsenic trioxide (As(2)O(3)) is an effective therapy in acute promyelocytic leukemia (APL), its use in other malignancies is limited by the toxicity of concentrations required to induce apoptosis in non-APL tumor cells. We looked for agents that would synergize with As(2)O(3) to induce apoptosis in malignant cells, but not in normal cells. We found that trolox (6-hydroxy-2,5,7,8-tetram...

Abbasi M Amidi F Minaei MB Nekoonam S Shabani Nashtaei M Takzare N

Background: Since the deleterious effects of reactive oxygen species (ROS) during sperm cryopreservation can be overcome by antioxidants, post-thaw human sperm quality may perhaps profit from adding antioxidants to the extender media prior to cryopreservation. This study evaluated the effects of different concentrations of Trolox supplementation to cryo-protective media on post-thaw motility an...

Journal: :The Journal of biological chemistry 2009
Jong-Ho Lee Ha-Neui Kim Daum Yang Kyoungsuk Jung Hyun-Man Kim Hong-Hee Kim Hyunil Ha Zang Hee Lee

Excessive receptor activator of NF-kappaB ligand (RANKL) signaling causes enhanced osteoclast formation and bone resorption. Thus, down-regulation of RANKL expression or its downstream signals may be a therapeutic approach to the treatment of pathological bone loss. In this study, we investigated the effects of Trolox, a water-soluble vitamin E analogue, on osteoclastogenesis and RANKL signalin...

Journal: :Neurotoxicology 2006
Bruce A O'Gara Phillip M Murray Erik M Hoyt Tifany Leigh-Logan Michael B Smeaton

The ability of the water-soluble Vitamin E analog, Trolox, to prevent the toxic effects of copper exposure on the behavior and neuronal physiology of the freshwater oligochaete Lumbriculus variegatus was examined. Trolox produced a concentration-dependent increase in the 24 h LC(50) for copper exposure, with 100 microM Trolox elevating the LC(50) by almost seven-fold (from 0.36 to 2.43 microM)....

Journal: :Investigative ophthalmology & visual science 2006
Allison Lindsay Dorfman Olga Dembinska Sylvain Chemtob Pierre Lachapelle

PURPOSE Previous studies have shown that newborn rats exposed to hyperoxia within the first 2 weeks of life develop vasculopathy in addition to permanent changes in retinal structure and function. It has also been suggested that free radicals may be the source of these pathologic effects. Trolox C, a water-soluble analogue of vitamin E, was previously shown to limit the vascular consequences of...

Journal: :مجله علوم اعصاب شفای خاتم 0
assrin babahajian cellular and molecular research center, iran university of medical science, tehran, iran. noorolhoda fotovat cellular and molecular research center, iran university of medical science, tehran, iran. mansureh soleimani cellular and molecular research center, iran university of medical science, tehran, iran.

ischemia has an important role in spread of pathologic injuries in the neuropathies. it is widely accepted that most damages such as reperfusion injuries, are related to the activity of free radicals. apoptotic signaling was exacerbated by free radicals. the aim of this study was to evaluate the neuroprotective effect of human chorionic gonadotropin (hcg) and vitamin e (trolox) in the hippocamp...

2016
Carlos Bondan Eraldo Zanella Ricardo Zanella Márcia Rósula Poetini Mariana Groke

Corresponding Author: Julio C.M. Soares Universidade Federal do PampaUNIPAMPA-Campus de Caçapava do Sul, RS, Brazila Email: [email protected] Abstract: The intensification of the use of artificial insemination in the swine industry has increased the interest to develop proper conditions to store semen better for longer periods of time without affecting its fertility. Trolox is a vitamin E ...

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