Malonic acid silylatesreadily to yield the expected bis-trimethylsilyl (TMS) ester; this ester reacts further in the silylating mixture to yield a tris-TMS derivative, apparently through enolization of one of the ester groups. Methylmalonic and hydroxymalonic acids behave similarly. The methyl and ethyl esters of malonic acid also silylate once with some facility. Mass spectra of these derivati...

In a three-step protocol involving regioselective enzymatic acylation, per-O-trimethylsilylation, and a one-pot α-glycosidation-deprotection sequence, cholesteryl-6-O-tetradecanoyl-α-D-glucopyranoside (α-CAG) of Helicobacter pylori is afforded starting from glucose in an overall yield of 45%. The production of CAG can be scaled to make purified quantities available to the biological community f...

A highly efficient CH3CN-promoted hexamethyldisilazane per-O-trimethylsilylation of amino sugars was developed. Its applications in homogenous N-functionalisation and a concise synthesis of glucosamine 6-phosphate are described.

A gas chromatographic procedure has been developed for the quantitative analysis of submicrogram amounts of the phenylthiohydantoins of all the amino acids except arginine. The compounds are divided into three groups according to their volatility and need for derivatization (trhnethylsilylation). The more volatile, relatively nonpolar thiohydantoins (Group I) are chromatographed with best resul...

Trimethylsilylation of alcohols and phenols were carried out under solvent-free conditions with hexamethyldisilazane (HMDS) using LaCoO3 perovskite. LaCoO3 as an efficient catalyst accelerated this reaction under milder condition. The advantages of this method are evident regarding, easy separation, low cost and low catalyst loading, lack of pollution, easy work-up, and selective protection of ...

a mild, efficient and fast method for the trimethylsilyl (tms), tetrahydropyranyl (thp) and methoxymethyl (mom) protection of alcohols and phenols in the presence of sulfonated rice husk ash (rha-so3h) is reported. all reactions were performed at room temperature in high to excellent yields. all the products are separated and compared with authentic samples and/ or identified using different ty...