Triazole fungicides associated with a range of reported male reproductive effects in experimental animals were selected to assess potential toxic modes of action. Wistar Han rats were fed myclobutanil (M: 100, 500, or 2000 ppm), propiconazole (P: 100, 500, or 2500 ppm), or triadimefon (T: 100, 500, or 1800 ppm) from gestation day 6 to postnatal day (PND) 120. One male per litter was necropsied ...

Triadimefon (Bayleton), a widely used triazole-type fungicide, affects gibberellin (GA) biosynthesis and 14 alpha-demethylase in sterol biosynthesis. The present study revealed that the phenotype of Arabidopsis treated with triadimefon resembled that of a brassinosteroid (BR)-biosynthesis mutant, and that the phenotype was rescued by brassinolide (BL), the most active BR, partly rescued by GA, ...

Exposure to environmental endocrine disruptors may interfere with nervous system's activity. Fungicides such as tebuconazole, triadimefon, and vinclozolin have antifungal activities and are used to prevent fungal infections in agricultural plants. In the present study, we studied effects of tebuconazole, triadimefon, and vinclozolin on rat's neurosteroidogenic 5α-reductase 1 (5α-Red1), 3α-hydro...

Different methods of applying triadimefon to sugarcane setts and to the soil at planting for the control of smut were tested in field trials. Immersing healthy setts in cold water containing 250 pglml triadimefon was beneficial when the setts were subsequently inoculated with smut before planting or grown under low levels of the disease, but was ineffective when smut was severe. Treating seedca...

This paper presents a study on the transfer and metabolism of triadimefon residues from rape flowers to apicultural products. In the field trials, honeybee colonies were placed in four rape greenhouses treated with triadimefon on standard dosage. Apicultural products (pollen, honey, and royal jelly) were collected on a regular basis. Sample preparation and extraction procedure were established....

Conazoles are a class of azole fungicides used to prevent fungal growth in agriculture, for treatment of fungal infections, and are found to be tumorigenic in rats and/or mice. In this study, cultured primary rat hepatocytes were treated to two different concentrations (0.3 and 0.15 mM) of triadimefon, which is a tumorigenic conazole in rat and mouse liver, on a temporal basis with daily media ...

The effectiveness of 12 chemical compounds (azoxystrobin, carbendazim, chlorothalonil, fenarimol, folpet, mancozeb, myclobutanil + mancozeb, prochloraz + carbendazim, tebuconazole + triadimefon, tetraconazole + chlorothalonil, tiophanate-methyl, tridemorph + epoxiconazole) in the control of Puccinia horiana was tested on chrysanthemum cv. Fiji Yellow. Additionally, their influence on plant grow...

Triadimefon is a widely used triazole fungicide known to cause severe developmental defects in several model organisms and in humans. The present study evaluated in detail the developmental effects seen in zebrafish embryos exposed to triadimefon, confirmed and expanded upon previous phenotypic findings and compared them to those observed in other traditional animal models. In order to do this,...

Triadimefon is a systemic agricultural fungicide of the triazole class whose major metabolite, triadimenol, also a commercial fungicide, provides the majority of the actual fungicidal activity, i.e., inhibition of steroid demethylation. Both chemicals are chiral: triadimefon has one chiral center with two enantiomers while its enzymatic reduction to triadimenol produces a second chiral center a...

The main objectives of this study wre to asses the effect of Triadimefon and Hexaconazole on the non-enzymatic antioxidant potentials of Manihot esculenta Crantz during the growth and maturation period. One litre of 20 mg L triadimefon and 15mg L hexaconazole solution per plant was used for the treatment -1 -1 and control was treated with one litre of irrigation water. The treatment was given o...