Cutaneous atrophy arising from prolonged use of potent topical corticosteroids has long been a concern. Thus, it would be advantageous to find an agent which protects against atrophy produced by corticosteroids but at the same time does not impair their anti-inflammatory effects. Recent work shows that topical all-trans retinoic acid (tretinoin) prevents skin atrophy in mice treated with topica...

This study was done to characterize the structural changes in the tretinoin pretreatment on trichloroacetic acid(TCA) chemical peel. In guinea pigs, the right halves pretreated with tretinoin and the left halves treated nothing were compared in their structural changes after TCA chemical peel. Epidermal thickness in the tretinoin pretreated group was almost the same in the first and second week...

Article history: Received on: 07/04/2013 Revised on: 28/04/2013 Accepted on: 13/05/2013 Available online: 30/07/2013 The objective of the present study was to formulate and evaluate Tretinoin proniosomal gel and to carry out comparative skin irritation study with conventional Tretinoin solution and Tretinoin conventional gel. Topical Tretinoin (0.25%, 0.05%) has been a reliable treatment of acn...

Acne vulgaris is a chronic and prevalent usually self-limited disorder. Topical medication is the main route for acne therapy. In this disorder the most widely used topical preparations are antibiotics such as Erythromycin and keratolytic agents such as Tretinoin. Excellent results with minimal side effects may be achieved by a fixed combination of Tretinoin and Erythromycin. This combination t...

Vitamin A-containing products have been used topically since the early 1940s to treat various skin conditions. To date, there are four generations of retinoids, a family of Vitamin A-containing compounds. Tretinoin, all-trans-retinoic acid, is a first-generation, naturally occurring, retinoid. It is available, commercially, as a gel or cream. The authors conducted a complete review of all studi...

Review locacid 0.05 tretinoin reviews Edinburgh BioQuarter, site of the University’s MRC Centre for Regenerative Medicine, and will draw how to buy isotretinoin online average cost of kitchen renovation perth The debate continues over whether it is worth the benefit, and whether the studies are biased by the manner patients are selected. tretinoin cream 0.025 for wrinkles isotretinoin generic p...

Tretinoin is known to be a pharmaceutical drug for treating acne vulgaris, keratosis pilaris, and acute promyelocytic leukemia. In order to reveal the possible conformers of tretinoin, the energies of all the conformers through rotational bonds have been evaluated by systematic rotor search analysis. The intramolecular interactions ranging from strong hydrogen bonds to weak van der Waals forces...

OBJECTIVE To evaluate the effect of copper tripeptide and tretinoin on normal and keloid-producing dermal fibroblasts in a serum-free in vitro model. The cellular response was described in terms of viability and secretion of basic fibroblast growth factor (bFGF) and transforming growth factor-beta1 (TGF-beta1). METHODS Primary cell lines were established from patient facial skin samples obtai...

The effect of 0.1% tretinoin cream for the treatment of photoageing was studied in a double-blind, placebo-controlled trial. All patients applied tretinoin cream to one forearm and the vehicle cream to the other, and half of the patients also applied tretinoin cream to the face and the other half used the vehicle cream. Tretinoin treatment produced an improvement in the signs of extrinsic agein...

OBJECTIVE To determine the efficacy and safety of short-contact administration of topical tretinoin on foot ulcers in patients with diabetes. DESIGN Randomized, double-blind, placebo-controlled trial. SETTING Outpatient clinic at a Veterans Affairs medical center. PATIENTS Twenty-four volunteers with diabetic foot ulcers but without evidence of peripheral arterial disease or infection. ...