نتایج جستجو برای: Transcriptomics

تعداد نتایج: 4822  

Journal: :The Journal of experimental biology 2015
Tyler G Evans

Transcriptomics has emerged as a powerful approach for exploring physiological responses to the environment. However, like any other experimental approach, transcriptomics has its limitations. Transcriptomics has been criticized as an inappropriate method to identify genes with large impacts on adaptive responses to the environment because: (1) genes with large impacts on fitness are rare; (2) ...

2012
Daniel J. Kliebenstein

Transcriptomics is a major platform to study organismal biology. The advent of new parallel sequencing technologies has opened up a new avenue of transcriptomics with ever deeper and deeper sequencing to identify and quantify each and every transcript in a sample. However, this may not be the best usage of the parallel sequencing technology for all transcriptomics experiments. I utilized the Sh...

Journal: :Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing 2017
Thomas Kamp Micah Adams Craig Disselkoen Nathan L. Tintle

Gene set analysis methods continue to be a popular and powerful method of evaluating genome-wide transcriptomics data. These approach require a priori grouping of genes into biologically meaningful sets, and then conducting downstream analyses at the set (instead of gene) level of analysis. Gene set analysis methods have been shown to yield more powerful statistical conclusions than single-gene...

2017
Rohan Lowe Neil Shirley Mark Bleackley Stephen Dolan Thomas Shafee

Transcriptomics technologies are the techniques used to study an organism's transcriptome, the sum of all of its RNA transcripts. The information content of an organism is recorded in the DNA of its genome and expressed through transcription. Here, mRNA serves as a transient intermediary molecule in the information network, whilst noncoding RNAs perform additional diverse functions. A transcrip...

Journal: :Microbiological Research 2007

Journal: :Archaea 2010

Journal: :Nature Reviews Genetics 2009

Journal: :Nature Methods 2016

2010
Jasper Walther Pawel Sierocinski John van der Oost

DNA microarray technology allows for a quick and easy comparison of complete transcriptomes, resulting in improved molecular insight in fluctuations of gene expression. After emergence of the microarray technology about a decade ago, the technique has now matured and has become routine in many molecular biology laboratories. Numerous studies have been performed that have provided global transcr...

2014
Marten Antoon Siemelink Tanja Zeller

The last years have witnessed tremendous technical advances in the field of transcriptomics that enable the simultaneous assessment of nearly all transcripts expressed in a tissue at a given time. These advances harbor the potential to gain a better understanding of the complex biological systems and for the identification and development of novel biomarkers. This article will review the curren...

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