This paper addresses the beginning of toxicokinetics in Spain by group Prof. Bartolomé Ribas 60s last century, as well interdisciplinary collaboration that occurs between academics Royal National Academy Pharmacy (RANF) and more specifically with Rafael Cadórniga, who was a pioneer Biopharmacy Pharmacokinetics studies Spain. scientific is magnificent example work strong interrelationship pharma...

in the current study, the effects of ethanol (etoh) on toxicokinetics of methamphetamine (ma) and its metabolite amphetamine (ap) were investigated. a single dose of ma hydrochloride at 15 mg/kg was given intragastrically, either alone (ma group; n = 8) or in conjunction with 3 g/kg etoh (ma+etoh group; n = 8) to rabbits. in placebo group, normal saline only was given (placebo group; n = 4). pl...

In this paper toxicokinetics was examined. Chemical distribution, absorption and elimination in the living organism were investigated. The aim of this paper kinetic of toxic substance during exposure in a biological system was studied. Several toxicokinetic models using physiological and biochemical parameters were derived. Physiologically based toxicokinetic models and similar pharmacokinetic ...

Existing protocols for antivenom treatment of snake envenomations are generally not well optimized due partly to inadequate knowledge of the toxicokinetics of venoms. The toxicokinetics of Naja sputatrix (Javan spitting cobra) venom was investigated following intravenous and intramuscular injections of the venom into rabbits using double-sandwich ELISA. The toxicokinetics of the venom injected ...