objective(s) quinazolinones are heterocyclic components (able to form cyclized compounds) which have several medical effects such as anti-malarial, spasmolytic, anti-microbial, sedative, etc. they are also known for their fungicidal properties, inhibition of tyrosine-kinase and dna repair enzyme poly (adp-ribose) polymerase (parp) and are also effective in treatment of cancer, diabetes, and par...

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a neurotoxin commonly used to produce an animal model of Parkinson's disease. Previous studies have suggested a critical role for neuronal nitric oxide (NO) synthase- (nNOS-) derived NO in the pathogenesis of MPTP. However, NO activity is difficult to assess in vivo due to its extremely short biological half-life, and so in vivo evidence of...

Objective(s) Quinazolinones are heterocyclic components (able to form cyclized compounds) which have several medical effects such as anti-malarial, spasmolytic, anti-microbial, sedative, etc. They are also known for their fungicidal properties, inhibition of tyrosine-kinase and DNA repair enzyme poly (ADP-ribose) polymerase (PARP) and are also effective in treatment of cancer, diabetes, and pa...