Xanthogranuloma is one of the 2 disorders of non-Langerhan cell histocytoses. It is a benign tumor histologically characterized by foamy histiocytes, numerous Touton giant cells and rare eosinophils. The histology differs from Langerhan cell histocytosis disorders in which convoluted histocytes, numerous eosinophils and rare Touton cells are seen. Grossly, the lesion appears as golden yellow pa...

Xanthogranulomatous inflammation is a form of chronic inflammatory process with collection foamy macrophages in sheets, often presence giant cell reaction. Here, we present case xanthogranulomatous osteomyelitis tibia 43 years old patient, which rare pathological entity and possibly was reported first 1984. The histopathological sections revealed dense lympho-plasmacytic infiltrate the marrow s...

This article briefly describes the named cells in dermatology. It‘s purpose is to serve as a ready reckoner to the postgraduates during their quiz preparations. They include the following: A. General category 1. Normal cutaneous anatomy: Langerhans cells, Glomus cells, Veil cells, Mast cells 2. Bullous disorders: Tzanck cells 3. Eczematous disorders: Tadpole cells 4. Metabolic and storage disor...

Juvenile xanthogranuloma (JXG) is an uncommon histiocytic cutaneous lesion. It is a type of non-Langerhans cell histiocytosis(WHO Class IIb). The mean age of onset is 2 years of age. The adult form of JXG is relatively rare. The most common affectedarea is the face or the scalp and most of the lesions are less than 5 mm in diameter. This lesion tends to show a self-limited course over several m...

INTRODUCTION Juvenile xanthogranuloma is a rare non-Langerhans cell histiocytosis that usually occurs during infancy and early childhood. The presence of single or multiple raised cutaneous lesions characterize this self-healing disorder. Extracutaneous sites are rare. CASE PRESENTATION We present a rare case of oral juvenile xanthogranuloma in a 49-year-old Caucasian woman. The histopatholog...

DEFINITION The histopathologic characteristics of ECD overlap xanthogranuloma and distinctions between the two are made on clinical and radiologic findings. Lipid-laden histocytes with foamy or eosinophilic cytoplasm infiltrate bones and various organs and generate a fibroblastic response that leads to critical organ failure. The histocytes are CD68+, Factor XIIIa+ CD1a-, S100-, and lack Birbec...

Biopsy was performed of one of the lesions: in the superficial dermis, beneath a normal epidermis, there was a diffuse proliferation of histiocytic cells with clear, foamy cytoplasm; in some areas Touton giant cells could be identified (Figure 2). There was also a moderate degree of vascular proliferation. Immunohistochemistry was positive for S100, CD68, and for CD34 (in the vessels) and was n...

giant cell glioblastoma is an extremely rare variant of glioblastoma (who grade iv) which is characterized by a predominance of bizarre, multinucleated giant cells. these tumors comprise of 0.8% of brain tumors and up to 5% of glioblastomas. in pediatric age group, these tumors are still uncommon with only around 53 published cases since 1952. here, we report a case of a 12-year old female pati...

giant cell tumors (gct) are benign tumors with potential for aggressive behavior and capacity to metastasize. although rarely lethal, benign bone tumors may be associated with a substantial disturbance of the local bony architecture that can be particularly troublesome in peri-articular locations. its histogenesis remains unclear. it is characterized by a proliferation of mononuclear stromal ce...