Background: Seborrheic dermatitis is one of the most common skin diseases. Objective: The purpose of this study was to compare the topical and oral ketoconazole in treatment of intractable cases of seborrheic dermatitis referring to Faghihi Hospital in Shiraz. Patients and Methods: This study was performed on 80 cases of intractable seborrheic dermatitis in 1376-1378. The patients were randomiz...

AIM Denture stomatitis is a common and recurring problem of denture wearers. Ketoconazole tablet is one of the antimycotic drugs that often has been used to treat this condition, but systemic use of this drug has some adverse effects that frequently lead to unfavorable compliance and treatment failure. This study was designed to compare the efficacy of topical ketoconazole 2% in orabase and ket...

A direct study evaluating whether differential drug uptake of topical 2% miconazole and 2% ketoconazole from cream formulations into human stratum corneum correlated with differential pharmacological activity against Candida albicans was investigated in healthy human subjects. A single 24-h topical dose of 2% ketoconazole cream or 2% miconazole cream was applied unoccluded, at the same dose (2....

Background: Acne vulgaris is a chronic inflammatory disease of pilosebaceous unit. The role of Pityrosporum ovale (P.ovale) in the exacerbation of acne is still under debate. Objective: To determine the efficacy of topical 2% ketoconazole cream in comparison to placebo in the treatment of acne vulgaris in patients with positive smear for P.ovale. Patients and Methods: A smear was obtained from ...

Ketoconazole topical is an antifungal medication. Ketoconazole topical prevents fungus from growing on your skin. The aim of the present investigation was to design and formulate an appropriate microspheres loaded gel (MLG), and explore the parameters affecting the morphology and other characteristics of the resultant products employing scanning electron microscopy (SEM). Microspheres loaded to...

This research focused on preparing a ketoconazole-infused silk fibroin hydrogel to enhance patient compliance, leveraging the hydrogel's biocompatibility and biodegradability. The process used 50% (v/v) ethanol, propanol, or glycerol solution treated with 2% (w/v) at 37°C. use of quickened gelation process. structure was analyzed via SEM, UV-VIS spectrometry evaluate encapsulation efficiency ke...

Background: Seborrheic dermatitis affects approximately 2 to 5% of the populace. Interestingly, the term ‘seborrheic dermatitis’ is somewhat a misnomer as there is no direct quantitative relationship between the degree of sebaceous activity and susceptibility to seborrheic dermatitis. Method: A pilot study was performed to initiate assessment of patient satisfaction with oral minocycline and to...

In order to assess the safety and efficacy of once-weekly fluconazole orally (100, 150, or 300 mg) with once-a-day topical application of 1% ketoconazole cream in the treatment of onychomycosis in Japan, 121 patients were assigned to one of three fluconazole dosages (100, 150, or 300 mg) and took fluconazole orally, once weekly, for 12 months or until a complete cure was achieved. In addition, ...