conclusions the results of this study show that the beneficial effect of lactobacillus casei is related to its metabolites. a formulated gel shows a significant antidermatophytosis activity compared to clotrimazole. results the results showed the same effect of the probiotic extract against 4 pathogens; however, the greatest average zone of inhibition was measured 34 mm against t. rubrum. the m...

the objective of this work was to develop bioadhesive topical gel of aceclofenac with the help of response-surface approach. experiments were performed according to a 3-level factorial design to evaluate the effects of two independent variables [amount of poloxamer 407 (pl-407 = x1) and hydroxypropylmethyl cellulose k100 m (hpmc = x2)] on the bioadhesive character of gel, rheological property o...

background: minoxidil has been reported to inhibit in vitro fibroblast proliferation and lysyl hydroxylase activity, a key enzyme in collagen biosynthesis. these in-vitro effects proposed minoxidil to be a potential antifibrotic agent. the present study aimed to investigate the effects of minoxidil gel on wound healing procedure in a second-degree burn model in rats.  materials and methods: wis...

objective: adequate knowledge about restorative materials particularly flowable composite resins with favorable physical properties like optimal microhardness and resistance to environmental factors is a big concern for many dentists. flowable composites have several applications for fissure sealant therapy and preventive resin restorations (prr) which are common treatments in pediatric dentist...

Uremic pruritus is a common and distressing symptom that affects more than 40% of patients undergoing hemodialysis. Several medications as well as topical preparation have been used for relief this condition. Sambucus ebulus has been shown anti-inflammatory and wound healing effects. In this research, the antipruritic effect of S. ebulus fruit extract was evaluated on patients with uremic pruri...

AIM   To clinically and histopathologically evaluate the anti-inflammatory effect of 0.2% hyaluronan gel alone and with mechanical therapy on gingivitis. The argyrophilic nucleolar organizer region staining technique was attempted to routinely determine its diagnostic and prognostic dependability for periodontal lesions. METHODS   In each of the 28 gingivitis patients, the four quadrants were...

BACKGROUND Topical silicone gel sheeting has been used for more than 20 years to help reduce the size of hypertrophic scars and keloids. Its clinical efficacy and safety is well established. OBJECTIVE To determine whether topical silicone gel sheeting can be used to prevent hypertrophic scars and keloids from forming following dermatologic skin surgery. METHODS Patients undergoing skin surg...

The inefficiency of current therapies of acne vulgaris, side effects and teratogenicity of topical and oral retinoids resulted in the need to find out new drugs. Adapalene 0.1% gel or solution with retinoid properties is effective in treatment of acne, and improves both inflammatory and non-inflammatory lesions. The anti-inflammatory properties of adapalene and its specific tendency to bi...

background: different treatment and protective approaches for radiation-induced oral mucositis have been practiced and have varieties of success. of which, radioprotective agents, synthetic or natural, have been of great interest for researchers. this study aims to evaluate the effect of curcuma longa topical gel as a herbal production on mucositis induced by radiation therapy of head and neck ...

Background: Different treatment and protective approaches for radiation-induced oral mucositis have been practiced and have varieties of success. Of which, radioprotective agents, synthetic or natural, have been of great interest for researchers. This study aims to evaluate the effect of curcuma longa topical gel as a herbal production on mucositis induced by radiation therapy of head and neck ...