statement of problem: early diagnoses of oral malignancies and pre-malignancies have direct effect in the outcome of these lesions. therefore the techniques for early diagnosis have been considered as useful method in practice. purpose: the aim of this study was to evaluate the reliability of oratest and generic toluidine blue (gtb) in the detection of oral malignancy and premalignancy. materia...

background: helicobacter pylori, which is associated with many upper gastrointestinal diseases, is found in half of the population of the world. several special stains and immunohistochemistry stain for h. pylori are available. the need for and usefulness of immunohistochemical (ihc) technique has been debated for years. toluidine blue is a simple stain for microbiological studies and is easily...

background: an enchondroma is a benign and a well-differentiated chondrosarcoma is an invasive chondroid tumor with high recurrence potential. in spite of biologic differences, these two tumors have very similar histopathologic appearance. it has been shown that the biologic nature of the connective tissue around benign and malignant tumors varies in the number of mast cells. the aim of this st...

Toluidine blue and toluidine blue-nanogold mixtures were incorporated into polyurethane and silicone polymers by a swell-encapsulation-shrink method using acetone-water mixtures. The surface and mechanical properties of the polymers were changed by the swell-shrink process especially the Young’s modulus, but not by the introduction of toluidine blue or nanogold. The antibacterial properties of ...

Toluidine blue is a basic thiazine metachromatic dye with high affinity for acidic tissue components, thereby staining tissues rich in DNA and RNA. It has found wide applications both as vital staining in living tissues and as a special stain owing to its metachromatic property. Toluidine blue has been used in vivo to identify dysplasia and carcinoma of the oral cavity. Use of toluidine blue in...

Objective behind the study was to assess the efficacy of Toluidine Blue (TB) mouth rinse in the detection of neoplasia in oral cavity and to evaluate its usefulness in high risk groups. Correlation of the results of scrape cytology smear and histopathology of biopsy taken from the TB stained area was also done. This prospective study was carried out on 85 cases of suspected oral lesions. Comple...

sulphide was determined spectrophotometrically at 628 nm and ph 6.7 based on its catalytic reduction of toluidine blue in the presence of se(iv) using a flow injection system. after optimization of the measuring conditions the calibration curve was found linear up to 25 mg/ml and the detection limit was 0.3 mg/ml (30 ml injections). the relative standard deviation for the determination of 10 mg...

Background: Helicobacter pylori, which is associated with many upper gastrointestinal diseases, is found in half of the population of the world. Several special stains and immunohistochemistry stain for H. pylori are available. The need for and usefulness of immunohistochemical (IHC) technique has been debated for years. Toluidine blue is a simple stain for microbiological studies and is easily...

BACKGROUND Surgical excision of the primary tumor with safe margins remains the mainstay of treatment for oral cavity squamous cell carcinoma (OSCC). The standard of care for assessment of intraoperative margins is frozen section histopathology. Unfortunately the facility is not available at most centers in limited resource countries. Toluidine blue, a metachromatic dye, has been well described...

There is a pressing need for the development of visual aids that will facilitate the detection of oral premalignant lesions (OPLs) with a high-risk of progression. Preliminary data suggest that toluidine blue stain may be preferentially retained by OPLs with high-risk molecular clones. In this study, we monitored OPLs from 100 patients without any history of oral cancer for an average of 44 mon...