the methanolic leaf extract of thuja occidentalis was evaluated for possible sedative activities in mice. sedative activity was evaluated by using hole cross, open field, thiopental sodium-induced sleeping time and elevated-plus maze (epm) tests at 200mg/kg and 400 mg/kg.  the extract decreased the locomotor activity of mice in hole cross, open field and epm test and showed the remarkable resul...

BACKGROUND AND PURPOSE Thiopental has been shown to protect against cerebral ischemic damage; however, it has undesirable side effects. We have examined how thiopental alters histological, physiological, and biochemical changes during and after hypoxia. These experiments should enable the discovery of agents that share some of the beneficial effects of thiopental. METHODS We made intracellula...

INTRODUCTION General anesthesia is required for Electroconvulsive Therapy (ECT) and it is usually provided by a hypnotic agent. The seizure duration is important for the treatment, and it is usually accompanied by severe hemodynamic changes. The aim of this study was to compare the effects of sodium thiopental versus Propofol on seizure duration and hemodynamic variables during ECT. METHODS A...

citicoline is a natural substance with neuroprotective and repairing effects. it can also increase the phosphor metabolites in cerebral cortex. regarding the various effects of citicoline on central nervous system, this research aims at studying the effects of citicoline on the thiopental sodium anesthesia. six dogs were anesthetized by intravenous injection of 20 mg ∕ kg of 2.5% thiopental sod...

background emergence agitation (ea) is a common problem in pediatric anesthesia. the current study evaluated the effect of intravenous lidocaine combined with propofol or thiopental sodium to control ea by sevoflurane in children. objectives the current study aimed to compare the effectiveness of two anesthesia regimen propofol–lidocaine and thiopental sodium lidocaine to control sevoflurane-in...

The aim of this study was to determine the effect of thiopental sodium with that of midazolam-ketamine on relieving agitation after tonsillectomy in children. In a clinical trial, 50 children aged 5-10 years, candidates for tonsillectomy, were randomly divided into two 25-member groups. In the first group, thiopental sodium 5mg/kg/IV, and in the second group combination of midazolam 0.01 mg/kg/...

thiopental sodium is an ultra short-acting barbiturate. due to its redistribution characteristic, its first injection has a short term effect. in order to elongate its anesthesia duration, more injections are needed. as these additional injections extend the recovery length , weaken respiration and causes other dangerous effects; its repeated use is considered unsafe. citicoline is a natural su...

the aim of this study was to determine the effect of thiopental sodium with that of midazolam-ketamine on relieving agitation after tonsillectomy in children. in a clinical trial, 50 children aged 5-10 years, candidates for tonsillectomy, were randomly divided into two 25-member groups. in the first group, thiopental sodium 5mg/kg/iv, and in the second group combination of midazolam 0.01 mg/kg/...

The purpose of this study was to evaluate the effects of thiopental versus propofol on cardiopulmonary functions, when used as an induction agent prior to isoflurane anesthesia in rhesus monkeys. Eight healthy rhesus monkeys weighing 3.72 to 5.7 kg, 4-5 years old, were used in the study. Anesthesia was induced with thiopental or propofol intravenous injection, and then maintained with isofluran...

Midazolam and sodium thiopental are two commonly used drugs in anesthesia for minor surgical procedures in children. A relationship exists between benzodiazepines (BNZ), barbiturates and melatonin. Whereas these drugs increase pineal melatonin production, the indoleamine amplifies the effects of both BNZ and barbiturates on the central nervous system (CNS). Our purpose was thus to analyze the p...