Present knowledge of the metabolic role of thioctic acid (lipoic acid) is derived almost exclusively from studies of bacterial enzyme systems, although it may well have similar functions in higher plants and animals. A number of microorganisms are known which have an absolute growth requirement for thioctic acid but higher animals do not seem to require preformed thioctic acid for growth. If ef...

Oxidative stress is an imbalance between the production of free radicals and antioxidant defense mechanisms, potentially leading to tissue damage. Oxidative stress has a key role in the development of cerebrovascular and/or neurodegenerative diseases. This phenomenon is mainly mediated by an enhanced superoxide production by the vascular endothelium with its consequent dysfunction. Thioctic, a...

Peripheral neuropathies are heterogeneous disorders presenting often with hyperalgesia and allodynia. This study has assessed if chronic constriction injury (CCI) of sciatic nerve is accompanied by increased oxidative stress and central nervous system (CNS) changes and if these changes are sensitive to treatment with thioctic acid. Thioctic acid is a naturally occurring antioxidant existing in ...

The r81e of thioctic acid in t’he oxidative decarboxylation of or-keto acids is now well established (1, 2). This was accomplished largely by studies with microbial cells grown essentially free of the cofactor. In some instances (2) it has been possible t,o separate the coenzyme from microbial enzymes involved in t,hioctic acid metabolism by extensive purification procedures. Although tjhe dire...

6-Ethyl-8-mercaptooctanoic acid, which bears a close chemical relationship to two functional forms of thioctic acid, 6,8-dimercaptooetanoic acid and 6-S-acetyl-6,8-dimercaptooetanoic acid, was found to be toxic for the growth of several microorganisms (Broquist and Stiffey, 1958). These effects were not nullified by thioctic acid, but were reversed competitively by a number of fatty acids inclu...

Mardonnes J, Segovia N, Hederra A, Alcaino F. Influence of sulfasuxidine on the effect of alpha lipoic or thioctic acid on the voluntary alcohol intake of rats depleted of factor N1. Acta Physiol Lat Am. 1953;3(2-3):140-3. PMID: 13138254 Abstract Mardonnes J, Segovia N, Alcaino F, Hederra A. Effect of synthetic thioctic or alpha lipoic acid on the voluntary alcohol intake of rats. Science. 1954...

This paper consti tutes a review of the exper imenta l events that l ed o u r l abo ra to ry to focus i t s attention on thioctic acid , a d i scuss ion of some of the pu re ly chemica l and physical p roper t ies of thioctic acid that this awakened i n t e r e s t p rompted us to invest igate , and a br ief descr ip t ion of some of o u r recen t biological investigations with thioctic acid.

Oligonucleotide gold nanoparticle conjugates are being used as diagnostic tools and gene silencing experiments. Thiol-chemistry is mostly used to functionalize gold nanoparticles with oligonucleotides and to incorporate DNA or RNA molecules onto gold surfaces. However, the stability of such nucleic acid-gold nanoparticle conjugates in certain conditions may be a limitation due to premature brea...

45 female patients with polycystic ovary syndrome took thioctic acid (Thioctacid-HR), 600 mg (n = 25) or high protein diet (n = 20). Fast insulin and glucose stimulus insulin were investigated before and after 3 months taken treatment. The use of thioctic acid, 600 mg is a new effective pathogenetics therapy of polycystic ovary syndrome on influence of hyperinsulinemia, HOMA-IR index and ovary ...

The electrochemical behavior of thioctic acid at the hanging mercury drop electrode was studied in different supporting electrolytes. In Britton - Robinson buffer pH 3.29, the square - wave adsorptive anodic stripping voltammogram of thioctic acid exhibited a single well - defined anodic peak at about -0.21 V vs Ag/AgCl. The peak response was characterized with respect to pH, preconcentration t...