objective: newbouldia laevis seem, is an ubiquitous perennial plant belonging to the family bignoniaceae with varying applicability in ethnomedicine. methods: the anticonvulsant effect of the aqueous extracts of root and stem bark preparations was undertaken using standard techniques. results: results showed that the ld50 in mice was 489.8mg/kg body weight while 5.6mg/kg body weight protected m...

statement of the problem subgingival irrigation with an antimicrobial agent after scaling and root planing (srp) is assumed to be able to kill the bacteria left behind after mechanical debridement. 3% h2o2 is used in the treatment of periodontal disease and it has been shown effective in killing anaerobic pathogens. purpose the aim of this study was to evaluate the clinical effects of subgingiv...

The exchange of a prescribed drug by other similar, by generic products and even by custom products has become common practice in our country, often ignoring basic tenets of bioequivalence, interchangeability, stability and characteristics of the pharmaceutical compounds. In the case of drugs of narrow therapeutic index, such as levothyroxine, these problems are intensified, putting the effecti...

PURPOSE The purpose of this computer simulation was to determine the likelihood of two bioequivalent (vs. reference) generic warfarin formulations (with varying bioavailability) passing current bioequivalence criteria against each other at varying bioavailability. Methods. A bioequivalence simulation program generated 100 warfarin bioequivalence (BE) studies with 24 patients/study. The referenc...

introduction: addiction is a habit or behavior that is often hard to quit. it is estimated that 190 million persons are substance users around the world. substance abuse creates tolerance after a while. shortly after taking the drug, a person will not enjoy as the beginning of its use that is why the amount of substance used is gradually increased. the purpose of this study was to find the reas...