Theranostic nanoparticles hold the potential to revolutionize disease management. Over the last decade, there has been growing interest in the engineering of various kinds of theranostic nanoparticles for simultaneous cancer imaging and therapy in small animals. Efficient targeting of theranostic nanoparticles to the tumor site is critical for both diagnosis and therapy. However, difficulties s...

Theranostic magnetic resonance imaging (MRI) is now receiving a growing interest in imaging-guided drug delivery, monitoring the treatment and personalized administration etc. Theranostic agents are essential for the usage of theranostic MRI. Among different kinds of theranostic agents, gadolinium loaded nanoparticles (GdNPs) are one of the most promising theranostic agents which are very promi...

Actively targeted theranostic nanomedicine may be the key for future personalized cancer management. Although numerous types of theranostic nanoparticles have been developed in the past decade for cancer treatment, challenges still exist in the engineering of biocompatible theranostic nanoparticles with highly specific in vivo tumor targeting capabilities. Here, we report the design, synthesis,...

1 During the last decade, there have been excellent and very rapid advances in “Nuclear Medicine and Molecular Imaging” throughout the world. The developments in radiopharmaceuticals induced evolution of nuclear medicine from imaging certain biologic features to targeted drug delivery designed for the specific characteristics of an individual patient’s disease. While the use of therapeutic radi...

It is highly desirable to develop theranostic nanoparticles for achieving cancer imaging with enhanced contrast and simultaneously multimodal synergistic therapy. Herein, we report a theranostic micelle system hierarchically assembling cyanine dye (indocyanine green) and chemotherapeutic compound (doxorubicin) (I/D-Micelles) as a novel theranostic platform with high drug loading, good stability...

Four new red BODIPY-gold(I) theranostic compounds were synthesized. Some of them were vectorized by tethering a biovector (glucose or bombesin derivatives) to the metallic center. Their photophysical properties were studied. Additionally, their cytotoxicity was examined on different cancer cell lines and on a normal cell line, they were tracked in vitro by fluorescence detection, and their upta...

Porphyrinic molecules have a unique theranostic role in disease therapy; they have been used to image, detect and treat different forms of diseased tissue including age-related macular degeneration and a number of different cancer types. Current focus is on the clinical imaging of tumour tissue; targeted delivery of photosensitisers and the potential of photosensitisers in multimodal biomedical...

One of the great engineering contributions to society has been the advent of feedback control to monitor and guide the operation of systems and devices, from maneuvering fighter jets to ensuring the safe operation of petrochemical plants. As healthcare moves toward the personalized medicine paradigm, it is becoming increasingly apparent that real-time feedback control strategies are needed to g...

The quest for early detection and treatment of diseases has led to intense research on theranostics [1]. With diagnosis and therapy combined onto a single platform, theranostics enables real-time monitoring of the status of disease treatment and allows for timely adjustment of type and dose of drugs, paving the way towards personalized medicine. The unique physiochemical properties of nanoparti...

Theranostic nanomedicines are a promising new technological advancement toward personalized medicine. Although much progress has been made in pre-clinical studies, their clinical utilization is still under development. A key ingredient for successful theranostic clinical translation is pharmaceutical process design for production on a sufficient scale for clinical testing. In this study, we rep...