Objective(s): Cirrhotic cardiomyopathy is a complication of uncured cirrhosis which is associated with hyporesponsiveness of the heart to sympathetic stimulation. The enhancement of portal pressure, nitric oxide (NO) level, pro-inflammatory mediators and down-regulation of Suppressor of Cytokine Signaling 1 (SOCS1) are involved in this situations. The present study see...

Thalidomide, a hypnosedative drug introduced in the 1950, has been used in a variety of dermatologic conditions during the past few decades. Although originally withbrawn from world market on discovery of its teratogenic effect, it has since been selectively reintroduced for use in various disorders thought to have an autoimmune or inflammatory basis. A review of the literature focused on clini...

Introduction: Idiopathic pulmonary fibrosis (IPF) is a relentlessly progressive and usually fatal lung disease of unknown etiology for which no effective treatments currently exist. In the adults type I and II pneumocytes, forms Components of the alveolar epithelial cells. In this study, we investigated the effect of thalidomide on the alveolar epithelial cells (type I and II pneumocytes) in ...

Background: Thalidomide has caused thalidomide embryopathy (TE) in more than 10,000 live-born children and is typically associated with phocomelia as well several other abnormalities such eye or ear malformations internal organ defects. Nowadays, survivors entered middle age, an age that susceptible to breast cancer women.

Backgrounds: Thalidomide has been used to treat ankylosing spondylitis (AS) patients, but the efficacy and safety of thalidomide on psychological symptoms sleep disturbances in patient with refractory AS not evaluated.

introduction: idiopathic pulmonary fibrosis (ipf) is a relentlessly progressive and usually fatal lung disease of unknown etiology for which no effective treatments currently exist. in the adults type i and ii pneumocytes, forms components of the alveolar epithelial cells. in this study, we investigated the effect of thalidomide on the alveolar epithelial cells (type i and ii pneumocytes) in th...

Thalidomide as an effective treatment for multiple myeloma and leprosy has also caused birth defects in thousands of children five decades ago particularly in Europe. Thus its use in humans remains limited. The rapid and fatal approval of thalidomide at that time ultimately was a consequence of the sole use of thalidomide-insensitive species in animal toxicity tests. Here, we aimed at elucidati...

There is growing clinical interest of thalidomide because of its immunomodulatory and antiangiogenic properties, despite its teratogenicity. However, little information about thalidomide has been reported regarding its precise effects on drug-metabolizing enzymes. We investigated the effects of thalidomide on cytochrome P450 (P450) enzymes in human liver microsomes to clarify the potential for ...

effect of thalidomide on TNF-a is not clear. Immune stimulation has been reported in scleroderma patients treated with thalidomide. In a randomized study comparing thalidomide vs. placebo in toxic epidermal necrolysis there was a paradoxical overproduction of TNF-a leading to excess mortality. There was a similar observation of increased plasma TNF-a and soluble TNF-a receptors with thalidomide...

Introduction: Several chemotherapeutic agents are currently available for the management of various malignancies; however, many associated with adverse effects. A case thalidomide- induced polyneuropathy is described below. Case Description: 65year old man, a history secondary myelofibrosis in thalidomide, consulted 5months neuropathic pain and paresthesia both hands. On physical examination, h...