background: many efforts have been undertaken until now to find an alternative approach to packed red cell tranfusion in major β-thalassemia. augmentation of fetal hemoglobin by hydroxyurea has proved to be less effective in this condition as compared to sickle cell anemia, probably due to molecular heterogeneity of the former disease. hydroxyurea efficacy and its relation to xmn1 polymorphism ...

conclusions there was insignificant correlation between serum hepcidin and ferritin levels in the two groups of patients with tm and ti. it seems that regulation of hepcidin in patients with thalassemia is more affected by erythropoeitic activity than iron stores. also, hepcidin levels were significantly higher in patients with tm than ti, possibly due to higher erythropoeitic activity in ti. i...

introduction: thalassemia is common in iran. appropriate therapy for this disease includes a regular blood transfusion and chelation therapy. however, patients will inevitably confront with side effects, particularly iron overloads in critical organ including heart, ductless glands and liver. this study tries to determine the prevalence of diabetes mellitus in transfusion dependent β thalassemi...

background: iran is a country located on the thalassemic belt of the globe. investigating such issues is of a greater significance in southern provinces of the country where the high prevalence of thalassemia has imposed high costs and mental pressure on families and the healthcare system. methods: in this cross-sectional study conducted in 2011 as a census, the data related to patients or dise...

background: major -thalassemia is the most common monogenic known disorder in iran and about 15000 persons are af fected. the purpose of this study was to evaluate the prevalence of orofacial complications. methods: in this cross-sectional study during 2003-2004, 300 patients with major -thalassemia referring to 8 hospitals for routine examinations, blood infusion and treatment in cities of teh...

introduction: there have been many reports and papers on deficient, normal and high levels of copper in patients with thalassemia major. the aim of this study is to evaluate copper status in a series of more than 300 patients with thalassemia major and determine the degree of copper deficiency or excess. methods: three hundred and seventy patients with thalassemia major over 5 years of age were...

background there are different and controversial reports about zinc deficiency in patients with major thalassemia. objectives the aim of this study was to evaluate zinc status in patients with major thalassemia in sistan and baluchistan province, southeastern iran. patients and methods the study was performed in ali asghar hospital, a specialized governmental hospital located in zahedan, iran. ...

β- thalassemia major is a common hemoglobinopathy in humans. in some journals, numerous studies have reported different prevalence of hepatitis c among β- thalassemia major because thalassemic patients need multiple blood transfusions and blood transfusion is a common transmission pathway for hepatitis c virus. thus this study was performed for detection of anti-hcv between β- thalassemia major...

background: the reproductive and sexual health issues concerning persons affected by thalassemia major are complex. the study was planned to investigate the psychological attitudes and expectations in a group of thalassemic pregnant women attending hospital for regular blood transfusion. methods : this is a preliminary cross-sectional study involving 20 consecutive thalassemic patients and a co...