The enzyme tyrosinase is known to be a multifunctional copper-containing enzyme from the oxidase superfamily, which is the key protein involved in the biosynthesis of the large biological pigment, melanin. The enzyme catalyzes two distinct reactions of melanin biosynthesis, the hydroxylation of a monophenol and the conversion of an o-diphenol to the corresponding o-quinone. Inhibitors of this p...

Based on the reaction of 1,6-diaryl-3, 4-dihydroxy-2, 4-hexadiene-1, 6-dione and arylidene-arylamines various 6-aryl-substituted-4-benzoylacetyl-4-hydroxy-5, 6-dihydro-4H-1, 3-oxazines were synthesized. Due to the relevance of search of new biologically active compounds with antioxidant activity, there was analyzed antiradical activity of derived oxazines. Antiradical properties of these compou...

A simple and ecofriendly method was developed for the synthesis of arylmethylene[bis(5,5- dimethyl-3-hydroxy-2-cyclohexene-1-ones)] from the reaction of 5,5-dimethylcyclohexane- 1,3-dione and aromatic aldehydes in an aqueous media without any catalyst via Knoevenagel condensation followed by rapid Michael addition. No cyclization product was down to convert these enolic forms to xanthene deriva...