1. The general features of the reaction by which carbon tetrachloride stimulates lipid peroxidation have been elucidated in rat liver microsomal suspensions and in mixtures of microsomes plus cell sap. The production of lipid peroxides has been correlated with malonaldehyde production in the systems used. 2. The stimulation of malonaldehyde production by carbon tetrachloride requires a source o...

Liver function tests, thyroxin and triiodothyronine levels, and hepatic 5’deiodinase and glutathione peroxidase enzyme activities were measured. Triiodothyronine levels in the carbon tetrachloride group and carbon tetrachloride + selenium group were significantly lower than in the control group (P<0.01, P<0.05, respectively). In the carbon tetrachloride + selenium group, the level of triiodothy...

Metabolism of carbon tetrachloride is essential for its toxic effect on intracellular components of the hepatocytes (Butler, 1961 ; Recknagel, 1967). Carbon tetrachloride decreases the biliary excretion of foreign organic compounds of high molecular weight (Barakat & Abou-El-Markarem, 1973). Whether metabolism of carbon tetrachloride is also essential for this effect, will be discussed here. Va...

The present study determines the efficacy of N-acetyl cysteine (NAC) on marker enzymes, lipid peroxidation and antioxidants in carbon tetrachloride induced hepatotoxicity in rats. Carbon tetrachloride (CCl4) (3 mL/kg/week) administered subcutaneously to albino Wistar rats for a period of three months significantly increased the activities of marker enzymes in plasma such as aspartate transamina...

Rat liver microsomal membranes contain a reduced-glutathione-dependent protein(s) that inhibits lipid peroxidation in the ascorbate/iron microsomal lipid peroxidation system. It appears to exert its protective effect by scavenging free radicals. The present work was carried out to assess the effect of this reduced-glutathione-dependent mechanism on carbon tetrachloride-induced microsomal injury...

The protective effects of 18beta-glycyrrhetinic acid (GA), the aglycone of glycyrrhizin (GL) derived from licorice, on carbon tetrachloride-induced hepatotoxicity and the possible mechanisms involved in this protection were investigated in mice. Pretreatment with GA prior to the administration of carbon tetrachloride significantly prevented an increase in serum alanine, aspartate aminotransfera...

The antioxidant effect of aqueous-ethanolic extract from Astragalus glycyphylloides (Fabaceae), and its protection against carbon tetrachloride-induced hepatotoxicity were investigated in male Wistar rats. For seven consequent days the animals were treated orally with A. glycyphylloides extract (EAG) (100 mg/kg). Two hours after the last administration the animals were charged with carbon tetra...

Recent work in our laboratory, carried out in collaboration with Dr. M. C. Schotz, has led to the formulation of a simple hypothesis regarding the pathogenesis of carbon tetrachloride fat accumulation. This hypothesis consists essentially of an extension of the work of Byers and Friedman (1) to the carbon tetrachloride-poisoned liver. These workers have recently shown that the liver is constant...

Recent work in our laboratory, carried out in collaboration with Dr. M. C. Schotz, has led to the formulation of a simple hypothesis regarding the pathogenesis of carbon tetrachloride fat accumulation. This hypothesis consists essentially of an extension of the work of Byers and Friedman (1) to the carbon tetrachloride-poisoned liver. These workers have recently shown that the liver is constant...

1. The effects of a number of free-radical scavengers and other agents on the stimulation of malonaldehyde production due to low concentrations of carbon tetrachloride have been studied in rat liver microsome suspensions. 2. Promethazine, propyl gallate and NN'-diphenyl-p-phenylenediamine were extremely active in inhibiting the stimulation of malonaldehyde production due to carbon tetrachloride...