objective: this study was designed to investigate the antinociceptive effect of chronic administration of the flavonoid hesperetin in streptozotocin-diabetic rats using formalin and hot tail immersion tests. materials and methods: rats were divided into 5 control groups, hesperetin-treated control, diabetic, sodium salicylate (ss)-treated diabetic, and hesperetin- and glibenclamide-treated dia...

background and objective: due to the presence of some evidence for anti-diabetic and antioxidant activity of tribulus terrestris (tt), this study was designed to investigate the anti-nociceptive effect of tt in streptozotocin-diabetic rats using formalin test and hot tail immersion tests. materials and methods: rats were divided into control, tt-treated control, diabetic, sodium salicylate (ss)...

introduction: hyperalgesia is considered as one of the marked signs of subchronic diabetes mellitus in patients that could affect their lifestyle. this study was designed to investigate the anti-nociceptive effect of chronic administration of quercetin in streptozotocin (stz)-diabetic rats using formalin and hot tail immersion tests. methods: rats were divided into control, control or diabetic ...

background and objective: hyperalgesia is one of the marked clinical signs of patients with diabetes mellitus that affects their lifestyle. this study was conducted to assess the anti-nociceptive effect of chronic administration of curcumin in streptozotocin (stz)-diabetic rats using formalin, hot tail immersion, and paw pressure tests. materials and methods: this study was conducted on 40 male...

objective: vitex agnus-castus (vac) and its essential oil have been traditionally used to treat many conditions and symptoms such as premenstrual problems, mastalgia, inflammation, sexual dysfunction, and pain. in this study, the effects of essential oil extracted from vitex agnus-castus (eovac) leaves were investigated in three behavioral models of nociception in adult male wistar rats. materi...

Introduction: Hyperalgesia is considered as one of the marked signs of subchronic diabetes mellitus in patients that could affect their lifestyle. This study was designed to investigate the anti-nociceptive effect of chronic administration of quercetin in streptozotocin (STZ)-diabetic rats using formalin and hot tail immersion tests. Methods: Rats were divided into control, control or diabetic ...

transcutaneous electrical nerve stimulation (tens) is an analgesia inducing method with increasing applications in clinical procedures. in this study we tried to evaluate the role of the adrenergic system and its different adrenoceptor subtypes in tens-induced analgesia. two types of low and high frequency electrical stimuli were used in rats through needle electrodes, inserted at the base of t...

Phencyclidine (1-(1-phenylcyclohexyl) piperidine, PCP, I) and ketamine (2-O-chlorophenyl-2-methylaminocyclohexan, II) have shown analgesic effects. Some of its derivatives were synthesized and their biological properties have been studied. In this study, a new derivative of PCP, (1-[1-(3-methoxyphenyl) (tetralyl)] piperidine, PCP-OCH3-tetralyl, III) was synthesized and the acute thermal pain ...

Phencyclidine (1-(1-phenylcyclohexyl) piperidine, PCP, I) and ketamine (2-O-chlorophenyl-2-methylaminocyclohexan, II) have shown analgesic effects. Some of its derivatives were synthesized and their biological properties have been studied. In this study, a new derivative of PCP, (1-[1-(3-methoxyphenyl) (tetralyl)] piperidine, PCP-OCH3-tetralyl, III) was synthesized and the acute thermal pain ...

background & aim: eugenia caryophyllata well known as clove is a tree from myrtaceae family that several parts of this plant traditionally used in dental care as an analgesic. this study aimed to assess the chemical composition, anti-inflammatory and anti-nociceptive activities of the essential oil extracted from clove buds. experimental: the essential oil of clove buds (eoc) was extracted ...