نتایج جستجو برای: TTF1

تعداد نتایج: 189  

Journal: :The Journal of pathology 2009
S Perner P L Wagner A Soltermann C LaFargue V Tischler B A Weir W Weder M Meyerson T J Giordano H Moch M A Rubin

Acquired chromosomal aberrations play an important role in tumour development and progression. Such genetic alterations occur in a significant proportion of non-small cell lung carcinomas (NSCLCs) and include amplification of 14q13.3, which contains the TTF1 gene. We asked whether TTF1 amplification is associated with increased TTF1 protein expression in NSCLCs, and whether TTF1 is associated w...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2015
Robert J G Cardnell Carmen Behrens Lixia Diao YouHong Fan Ximing Tang Pan Tong John D Minna Gordon B Mills John V Heymach Ignacio I Wistuba Jing Wang Lauren A Byers

PURPOSE Thyroid transcription factor-1 (TTF1) immunohistochemistry (IHC) is used clinically to differentiate primary lung adenocarcinomas (LUAD) from squamous lung cancers and metastatic adenocarcinomas from other primary sites. However, a subset of LUAD (15%-20%) does not express TTF1, and TTF1-negative patients have worse clinical outcomes. As there are no established targeted agents with act...

Journal: :The Journal of clinical investigation 2002
Joachim Pohlenz Alexandra Dumitrescu Dorothee Zundel Ursula Martiné Winfried Schönberger Eugene Koo Roy E Weiss Ronald N Cohen Shioko Kimura Samuel Refetoff

Three genes, TTF1, TTF2, and PAX8, involved in thyroid gland development and migration have been identified. Yet systematic screening for defects in these genes in thyroid dysgenesis gave essentially negative results. In particular, no TTF1 gene defects were found in 76 individuals with thyroid dysgenesis even though a deletion of this gene in the mouse results in thyroid and lung agenesis and ...

Journal: :Molecules 2016
Bin Xiao Dongjing Lin Xuan Zhang Meilan Zhang Xuewu Zhang

TTF1-NP (5,2',4'-trihydroxy-6,7,5'-trimethoxyflavone nanoparticles), derived from the traditional Changbai Mountain medicinal plant Sorbaria sorbifolia (SS), has been showed its anti-cancer effect in various liver cancer cell types and tissues. The present study was designed to evaluate the antitumor mechanism of the TTF1-NP against HepG2 hepatoma cells and HepG2 cells-induced hepatocarcinoma (...

Journal: :Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 2000
A Feliciello G Allevato A M Musti D De Brasi A Gallo V E Avvedimento M E Gottesman

Thyroid transcription factor 1 (TTF1) is a nuclear homeodomain protein that binds to and activates the promoters of several thyroid-specific genes, including that of the thyroglobulin gene (pTg). These genes are also positively regulated by thyroid-stimulating hormone/cyclic AMP (cAMP)/protein kinase A (PKA) signaling. We asked whether PKA directly activates TTF1. We show that cAMP/PKA activate...

Journal: :Oncology reports 2011
Yan Li Lei Bian Fengde Cui Liangchang Li Xuewu Zhang

The Chinese medicinal herb Sorbaria sorbifolia, native to Changbai Mountain, can induce apoptosis in HepG-2 cells. We studied the mechanism by which 5, 2', 4'-trihydroxy-6,7, 5'-trimethoxyflavone (TTF1) isolated from acetic ether extracts of Sorbaria sorbifolia induces apoptosis in HepG-2 cells. The results showed that TTF1 both inhibited cell growth and induced apoptosis. RT-PCR and Western bl...

2016
Ana Lopez-Campistrous Esther Ekpe Adewuyi Matthew G.K. Benesch Yi Man Ko Raymond Lai Aducio Thiesen Jay Dewald Peng Wang Karen Chu Sunita Ghosh David C. Williams Larissa J. Vos David N. Brindley Todd P.W. McMullen

Dedifferentiation of follicular cells is a central event in resistance to radioactive iodine and patient mortality in papillary thyroid carcinoma (PTC). We reveal that platelet derived growth factor receptor alpha (PDGFRα) specifically drives dedifferentiation in PTC by disrupting the transcriptional activity of thyroid transcription factor-1 (TTF1). PDGFRα activation dephosphorylates TTF1 cons...

Journal: :International journal of clinical and experimental pathology 2014
Jinhai Yan Qingzhu Wei Wenjing Jian Jianghuan Liu Hongping Tang Juan Ge Jie Zhou Tong Zhao

The utility of combination with CK5/6, IMP3 and TTF1 to differentiate among reactive mesothelial cells (RMs), metastatic adenocarcinoma of lung (LAC) and non-lung (NLAC) origin was investigated by using immunocytochemistry (ICC) and conventional PCR (C-PCR) in pleural effusion. A total of 108 cell blocks (32 RMs, 51 LAC and 25 NLAC were evaluated by ICC for CK5/6, IMP3 and TTF1 protein expressi...

Journal: :Diagnostic cytopathology 2007
Weijian Zhu Claire W Michael

The distinction between metastatic adenocarcinomas of lung (LAC), breast (BAC), and ovary (OAC) in serous effusions can be very difficult since they all can present as tight cell clusters. This is particularly challenging when the malignant effusion is the patient's initial presentation or when the patient has a history of more than one primary. The aim of this study is to evaluate the usefulne...

2017
Robert J. Cardnell Lerong Li Triparna Sen Rasha Bara Pan Tong Junya Fujimoto Abbie S. Ireland Matthew R. Guthrie Sheila Bheddah Upasana Banerjee Nene N. Kalu You-Hong Fan Scott J. Dylla Faye M. Johnson Ignacio I. Wistuba Trudy G. Oliver John V. Heymach Bonnie S. Glisson Jing Wang Lauren A. Byers

Small cell lung cancer (SCLC) is a recalcitrant cancer for which no new treatments have been approved in over 30 years. While molecular subtyping now guides treatment selection for patients with non-small cell lung cancer and other cancers, SCLC is still treated as a single disease entity. Using model-based clustering, we found two major proteomic subtypes of SCLC characterized by either high t...

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