Background: In Archaea, previous studies have revealed the presence of multiple intron-containing tRNAs and split tRNAs. The full unexpurgated analysis of archaeal tRNA genes remains a challenging task in the field of bioinformatics, because of the presence of various types of hidden tRNA genes in archaea. Here, we suggested a computational method that searched for widely separ...

background: mitochondria are autonomous cellular organelles that oversee a variety of functions such as metabolism, energy production, calcium buffering, and cell fate determination. most recently, mitochondrial dysfunction caused by mitochondrial mutations played important roles in the pathogenesis of asthma. however, the frequency of mitochondrial trna mutations in asthma is largely unknown. ...

background and objectives: enteropathogenic escherichia coli (epec) divided into two groups typical and atypical (aspect). the main virulence genes are located in a pathogenicity island called lee ( locus of enterocyte effacement ). lee frequently inserted in trna genes of selc , pheu and phev in the bacterial chromosome. tepec and aepec strains have some differences in their pathogenicity. the...

Abstract BACKGROUNDS Transfer RNA (tRNA) is the most extensively modified in cells. Queuosine (Q)-modification a fundamental process for fidelity and efficiency of translation from to proteins. In eukaryotes, tRNA-Q-modification relies on intestinal microbial product queuine. Growing evidence indicates that tRNA modifications play important roles human diseases, e.g., type 2 diabetes. Q depleti...

background: mitochondrial transfer rnas (trna) genes are essential components of protein biosynthesis. these genes are hotspots for mutations. these mutations are associated with a wide spectrum of human disease. many genetic factors are known in assessment of repeated pregnancy loss (rpl). objective: the aim of this study was analysis of trna thr and trna pro in women with rpl. materials and m...

Background: In Neurospora crassa, the circadian clock controls rhythmic mRNA translation initiation through regulation of eIF2α kinase CPC-3 (the homolog yeast and mammalian GCN2). Active phosphorylates inactivates eIF2α, leading to higher phosphorylated (P-eIF2α) levels reduced during subjective day. This daytime activation is driven by its ...