نتایج جستجو برای: TNP

تعداد نتایج: 816  

2016
Ling-Lei Kong Guo-Lin Shen Zhi-Yuan Wang Xiao-Mei Zhuang Wei-Bin Xiao Mei Yuan Ze-Hui Gong Hua Li

Thienorphine (TNP) is a novel partial opioid agonist that has completed phase II clinical evaluation as a promising drug candidate for the treatment of opioid dependence. Previous studies have shown that TNP and its glucuronide conjugate (TNP-G) undergo significant bile excretion. The purpose of this study was to investigate the roles of efflux transporters in regulating biliary excretion and p...

Journal: :The Journal of Experimental Medicine 1982
J C Cambier J G Monroe M J Neale

In an effort to further elucidate the early cellular events in generation of antibody responses, we have determined the requirements for antigen-specific initiation of the G0 to G1 transition by isolated trinitrophenol (TNP) -binding B lymphocytes. TNP-binding cells were isolated from normal B6D2F1 splenocyte populations using hapten affinity fractionation on disulfide-bonded TNP-gelatin-coated...

Journal: :Investigative ophthalmology & visual science 1983
J C Waldrep H J Kaplan

The relationship between the anterior chamber (AC) of the eye and the immune system was studied after intracameral inoculation with the hapten TNP. Injection of syngeneic TNP-modified splenocytes (TNP-Sp) into the AC of Balb/c mice results in suppressed systemic cell-mediated immunity to TNP as determined by the ear swelling assay. This aberrant immune responsiveness following AC injection of T...

Journal: :The Journal of pharmacology and experimental therapeutics 2009
Srividya Suryanarayana Martin Göttle Melanie Hübner Andreas Gille Tung-Chung Mou Stephen R Sprang Mark Richter Roland Seifert

Adenylyl cyclases (ACs) catalyze the conversion of ATP into the second messenger cAMP and play a key role in signal transduction. In a recent study (Mol Pharmacol 70:878-886, 2006), we reported that 2',3'-O-(2,4,6-trinitrophenyl)-substituted nucleoside 5'-triphosphates (TNP-NTPs) are potent inhibitors (K(i) values in the 10 nM range) of the purified catalytic subunits VC1 and IIC2 of membranous...

Journal: :The Journal of Experimental Medicine 1980
J J Jandinski J Li P J Wettstein J A Frelinger D W Scott

Trinitrophenylated syngeneic spleen cells (TNP-SC) are potent tolerogens of the anti-TNP plaque-forming cell (PFC) response in vivo and in vitro. This unresponsive state requires T cells for both its induction and maintenance. Because H-2K/D-restricted cytotoxic T cells are also induced by exposure to TNP-SC, we determined the role(s) of histocompatibility antigens (K, I, and D) in the suppress...

Journal: :Nucleic Acids Research 2006
Mindy Steiniger Christian D. Adams John F. Marko William S. Reznikoff

While non-specific DNA plays a role in target localization for many recombinases, transcription factors and restriction enzymes, the importance of non-specific DNA interactions for transposases has not been investigated. Here, we discuss non-specific DNA-Tn5 Transposase (Tnp) interactions and suggest how they stabilize the Tnp and modulate Tnp localization of the 19 bp Tnp recognition end seque...

Journal: :Journal of molecular biology 1998
M Zhou A Bhasin W S Reznikoff

Transposition of Tn5 and IS50 requires the specific binding of transposase (Tnp) to the end inverted repeats, the outside end (OE) and the inside end (IE). OE and IE have 12 identical base-pairs and seven non-identical base-pairs. Previously we described the isolation of a Tnp mutant, EK54, that shows an altered preference for OE versus IE compared to wild-type (wt) Tnp. EK54 enhances OE recogn...

Journal: :Environmental science & technology 2011
Tadashi Toyama Manabu Murashita Kazutaka Kobayashi Shintaro Kikuchi Kazunari Sei Yasuhiro Tanaka Michihiko Ike Kazuhiro Mori

We investigated biodegradation of technical nonylphenol (tNP) in Phragmites australis rhizosphere sediment by conducting degradation experiments using sediments spiked with tNP. Accelerated tNP removal was observed in P. australis rhizosphere sediment, whereas tNP persisted in unvegetated sediment without plants and in autoclaved sediment with sterile plants, suggesting that the accelerated tNP...

Journal: :Medžiagotyra 2022

Water quality directly affects human health. It is very important to design a probe that can detect the pollutants in water. In this study, we synthesized one kind of carbon dots (CDs), which could emit strong blue fluorescence. The fluorescence be quenched by 2,4,6-trinitrophenol (TNP) ascribed energy transfer (ET), lemon yellow (LY) inner filter effect (IFE), and HClO surface passivation (SP)...

Journal: :The Journal of Experimental Medicine 1976
S J Burakoff R N Germain B Benacerraf

Normal spleen cells, when cultured with irradiated trinitrophenyl (TNP)-derivatized syngeneic spleen cells, develop cytotoxic effectors that lyse most effectiviely a TNP-derivatized target that is H-2 compatible with the effector. However, these effectors also lyse to a lesser extent TNP tumor and TNP spleen targets that are H-2 incompatible. This cross-reactive lysis correlates with the degree...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید