This study was designed to find out the impact of the variable number of tandem repeats (VNTR) of the tumor necrosis factor receptor 2 (TNFRSF1B) on pulmonary tuberculosis (PTB) risk in an Iranian population. This case-control study was done on 159 PTB patients and 158 healthy subjects. Bi-allelic TNFRSF1B VNTR was genotyped by polymerase chain reaction. Logistic regression analysis revealed no...

Neuroinflammation is a known factor in the pathogenesis of recurrent depressive disorders. Depression is accompanied by activated immune-inflammatory pathways including increased levels of TNFα, sTNFR1and sTNFR2.The purpose of this study was to analyse the TNF-α, TNFRSF1A and TNFRSF1B genes on both mRNA and protein levels in patients with rDD, and to investigate the relationship between TNF-α,T...

BACKGROUND Currently definitive 5-fluorouracil (5-FU)/cisplatin (CDDP) -based chemotherapy is recognized as one of the most promising treatments for esophageal cancer. A series of studies performed found genetic polymorphisms and the plasma concentration of 5-FU to be predictive of acute severe toxicities and clinical response. Genetic polymorphisms of tumor necrosis factor (TNF) -alpha and its...

This study was designed to find out the impact of the variable number of tandem repeats (VNTR) of the tumor necrosis factor receptor 2 (TNFRSF1B) on pulmonary tuberculosis (PTB) risk in an Iranian population. This case-control study was done on 159 PTB patients and 158 healthy subjects. Bi-allelic TNFRSF1B VNTR was genotyped by polymerase chain reaction. Logistic regression analysis revealed no...

BACKGROUND The interaction of tumor necrosis factor-α (TNF-α) with its receptors: TNFRSF1A and TNFRSF1B is critical for the promotion of tumor growth, invasion and metastasis. To better understand the roles of single nucleotide polymorphisms (SNPs) in the TNF-α, TNFRSF1A and TNFRSF1B genes in the development of breast cancer, we explored the associations between SNPs in these three genes and br...

this study was designed to find out the impact of the variable number of tandem repeats (vntr) of the tumor necrosis factor receptor 2 (tnfrsf1b) on pulmonary tuberculosis (ptb) risk in an iranian population. this case-control study was done on 159 ptb patients and 158 healthy subjects. bi-allelic tnfrsf1b vntr was genotyped by polymerase chain reaction. logistic regression analysis revealed no...

Juvenile idiopathic arthritis (JIA) is the most frequent rheumatic disease in children and could lead to severe disability. The aim of this study was to determine the role of gene polymorphisms in predicting the clinical response of anti-TNF therapy in JIA patients. 68 patients with JIA and 20 healthy controls (HC) were included in the study, and patients with JIA received anti-TNF treatment fo...

Background: Gastric cancer (GC) is one of the most common malignancies worldwide. To date, the polymorphisms in the promoter region of tumour-necrosis factor-α (TNF-α) gene have been extensively studied in relation to different kinds of cancer, including GC. Methods and materials: In this case-control study, the case population consisted of 240 GC cases and 510 healthy controls. Genotyping of T...

The TNFR2 receptor is expressed by highly active regulatory T cells, and thus constitutes an important therapeutic target for the treatment of autoimmune disease and cancer. Disease susceptibility as well as the potential response to therapies directed at TNFR2 could be significantly impacted by genetic variation in the promoter of the TNFRSF1B gene that codes for the TNFR2 protein. To date, on...

OBJECTIVE Genetic variation in the tumor necrosis factor (TNF) receptor 2 gene (TNFRSF1B) has shown association with insulin resistance in type 2 diabetes, hypercholesterolemia, coronary artery disease, and essential hypertension. Here we tested the TNFRSF1B marker used in the latter studies in type 2 diabetes patients. RESEARCH DESIGN AND METHODS A case-control study of a microsatellite mark...