نتایج جستجو برای: TNBS

تعداد نتایج: 810  

Journal: :Duzce Universitesi Tip Fakültesi Dergisi 2021

Aim: In this study, it was aimed to investigate the effects of beta glucan (BG) on experimental colitis model created by using trinitrobenzene sulfonic acid (TNBS). Material and Methods: Thirty-two Wistar Albino rats were divided equally into four groups as sham control, TNBS, TNBS-BG3, TNBS-BG10 groups. While saline administrated group, TNBS administered intrarectally under anesthesia. BG at a...

2016
Su-Min Lim Hyun Sik Choi Jin-Ju Jeong Seung-Won Han Dong-Hyun Kim

We investigated the effect of DWac on the gut microbiota composition in mice with 2,3,6-trinitrobenzenesulfonic acid- (TNBS-) induced colitis. Treatment with DWac restored TNBS-disturbed gut microbiota composition and attenuated TNBS-induced colitis. Moreover, we examined the effect of DWac in mice with mesalazine-resistant colitis (MRC). Intrarectal injection of TNBS in MRC mice caused severe ...

Journal: :The Astronomical Journal 2022

Within the dynamically cold low inclination portion of Classical Kuiper Belt, there exists a population weakly bound binary systems with number unusual properties; most notable which is their extremely wide orbital separations; beyond 7% Hill radii. The stability and evolution these Ultra-Wide Trans-Neptunian Binaries (TNBs) have, in past, been studied extensively under assumption that primary ...

2015
Caroline de Souza Almeida Vinicius Andrade-Oliveira Niels Olsen Saraiva Câmara Jacqueline F. Jacysyn Eliana L. Faquim-Mauro

Inflammatory bowel diseases (IBD) is the result of dysregulation of mucosal innate and adaptive immune responses. Factors such as genetic, microbial and environmental are involved in the development of these disorders. Accordingly, animal models that mimic human diseases are tools for the understanding the immunological processes of the IBD as well as to evaluate new therapeutic strategies. Cro...

2013
Duan-Yong Liu Chun-Shui Pan Yu-Ying Liu Xiao-Hong Wei Chang-Man Zhou Kai Sun Ke He Chong Li Li Yan Jing-Yu Fan Chuan-She Wang Toshifumi Hibi Hong-Ning Liu Jing-Yan Han

Huang Qi Jian Zhong Pellet (HQJZ) is a famous Chinese medicine formula for treatment of various gastrointestinal tract diseases. This study investigated the role of HQJZ in 2,4,6-trinitrobenzene sulfonic acid- (TNBS-) induced colitis and its underlying mechanism. Colonic mucosal injury was induced by TNBS in the Sprague-Dawley rats. In the HQJZ treatment group, HQJZ was administered (2 g/kg) fo...

2014
Zita Szalai Krisztina Kupai Médea Veszelka Anikó Pósa Szilvia Török Anikó Magyariné Berkó Zoltán Baráth Ferenc A. László Csaba Varga

The 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced acute inflammatory bowel disease (IBD) model in the rat is discussed, focusing on the details of the TNBS instillation and highlighting the advantages and limitations of this model. For determination of the timedependent action of 50% ethanol and different doses of TNBS, male Wistar rats were treated with 50% ethanol or 10 mg or 30 mg of TNB...

2017
Chen-yang Zhi Zhe Lv Ning Kong Yan Chen Zhe-hui Wang Hai-cheng Gao

Purpose: In this study, the effect on heart, kidneys and liver organs in TNBS-induced Ulcerative colitis was investigated. Method: Twenty mice were randomly divided into two groups, which included normal group and model group. The model of chronic colitis was induced by 50% TNBS. The model of chronic colitis was verified by body weight, H&E staining. Heart, kidneys and liver organs were tested ...

Journal: :Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 2010
M A Engel C A Kellermann G Burnat E G Hahn T Rau P C Konturek

This study was performed to assess whether mice lacking the cannabinoid receptor CB1, CB2 or both receptors show increased susceptibility to TNBS colitis in comparison to wildtype mice. Previously, activation of CB1 and CB2 receptors showed attenuation of TNBS colitis in mice. The aim of the study was to investigate the susceptibility of three mouse strains CB1-, CB2- and CB1+2 double knockout ...

2012
Tomohisa Takagi Yuji Naito Kazuhiko Uchiyama Toshimitsu Okuda Takahiro Suzuki Hisato Tsuboi Katsura Mizushima Osamu Handa Nobuaki Yagi Hiroshi Ichikawa Toshikazu Yoshikawa

UNLABELLED BACKGROUND The pathogenesis of inflammatory bowel disease (IBD) is complex, and an effective therapeutic strategy has yet to be established. Recently, carbon monoxide (CO) has been reported to be capable of reducing inflammation by multiple mechanisms. In this study, we evaluated the role of colonic CO insufflation in acute colitis induced by trinitrobenzene sulfonic acid (TNBS) i...

Journal: :American journal of physiology. Gastrointestinal and liver physiology 2012
Bin Feng Jun-Ho La Takahiro Tanaka Erica S Schwartz Timothy P McMurray G F Gebhart

Inflammation of the distal bowel is often associated with abdominal pain and hypersensitivity, but whether and which colorectal afferents contribute to the hypersensitivity is unknown. Using a mouse model of 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis, we investigated colorectal hypersensitivity following intracolonic TNBS and associated changes in colorectum and afferent functio...

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