نتایج جستجو برای: TNA

تعداد نتایج: 313  

Journal: :Nucleic Acids Research 2005
Justin K. Ichida Allen Horhota Keyong Zou Larry W. McLaughlin Jack W. Szostak

Therminator DNA polymerase is an efficient DNA-dependent TNA polymerase capable of polymerizing TNA oligomers of at least 80 nt in length. In order for Therminator to be useful for the in vitro selection of functional TNA sequences, its TNA synthesis fidelity must be high enough to preserve successful sequences. We used sequencing to examine the fidelity of Therminator-catalyzed TNA synthesis a...

Journal: :Journal of the American Chemical Society 2003
John C Chaput Justin K Ichida Jack W Szostak

TNA, or threose nucleic acid, is capable of Watson-Crick base pairing with DNA, RNA, and TNA; coupled with its chemical simplicity, this suggests that TNA is a possible progenitor of RNA. As an initial step toward developing the molecular tools necessary to investigate the functional capabilities of TNA by in vitro selection, we have screened a variety of DNA polymerases for activity on a TNA t...

Journal: :Journal of Bacteriology 1977

Journal: :Journal of the American Chemical Society 2003
John C Chaput Jack W Szostak

Threose nucleic acid (TNA), which has a repeat unit one atom shorter than that of DNA, is capable of Watson-Crick base pairing with DNA, RNA, and TNA. Because of its chemical simplicity, TNA is considered to be a possible progenitor of RNA. As an initial step toward developing the molecular tools necessary to investigate the functional capabilities of TNA by in vitro selection, we have screened...

Journal: :Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition 2015
Jane Gervasio

Total nutrient admixture (TNA) is a complete parenteral nutrition (PN) formulation composed of all macronutrients, including dextrose, amino acids, and intravenous fat emulsions (IVFE), in one bag. The TNA may be safely administered to the patient, with all components aseptically compounded and minimal administration manipulation required, lending itself to decreases in risks of catheter contam...

2005
Justin K. Ichida Keyong Zou Allen Horhota Biao Yu Larry W. McLaughlin Jack W. Szostak

(3'-2')-alpha-l-Threose nucleic acid (TNA) is an unnatural polymer that possesses the rare ability to base-pair with RNA, DNA, and itself. This feature, coupled with its chemical simplicity, makes TNA of interest as a possible progenitor of RNA during the early history of life. To evaluate the functional potential of TNA, we have developed a system for the in vitro selection of TNA. We identifi...

2005
Allen Horhota Keyong Zou Justin K. Ichida Biao Yu Larry W. McLaughlin Jack W. Szostak John C. Chaput

alpha-l-Threofuranosyl nucleoside triphosphates (tNTPs) are tetrafuranose nucleoside derivatives and potential progenitors of present-day beta-d-2'-deoxyribofuranosyl nucleoside triphosphates (dNTPs). Therminator DNA polymerase, a variant of the 9 degrees N DNA polymerase, is an efficient DNA-directed threosyl nucleic acid (TNA) polymerase. Here we report a detailed kinetic comparison of Thermi...

2005
Zografos Caramanos Sridar Narayanan Douglas L. Arnold

Meta-analysis was performed on the results of 75 comparisons from the 30 peer-reviewed publications that used proton magnetic resonance spectroscopy (H-MRS) or spectroscopic imaging to (i) quantify the mean concentrations of total creatine (tCr, found in neurons, astrocytes and oligodendrocytes), and/or total N-acetyl groups (tNA, found only in neurons), in the lesional and/or non-lesional whit...

2006
Mi-Jung Choi Hong-Taek Ju James Won-Ki Hong Dong-Sik Yun

To avoid frequent changes of OSS's architecture, TNA provides NGOSS architecture in technology-neutral manner. TNA can be mapped to appropriate TSAs using specific technologies such as XML, Java and CORBA. Web Service can be applied for NGOSS TSA. In this paper, we examine architectural principles of TNA and propose an application mechanism of Web services technologies to TNA.

Journal: :The Journal of bone and joint surgery. British volume 2001
N Tanaka H Sakahashi E Sato K Hirose T Ishima S Ishii

We studied 99 patients who were undergoing total knee arthroplasty (TKA) to determine the optimum protocol for the administration of tranexamic acid (TNA) in order to reduce blood loss. It decreased by more than 40% after the administration of TNA. The haemostatic effect was greatest when TNA was given preoperatively and on deflation of the tourniquet. There was no increase in the incidence of ...

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