Tilmicosin (TLM) is an important antibiotic in veterinary medicine with low bioavailability and safety. This study aimed to formulate and evaluate physicochemical properties, storage stability after lyophilization and antibacterial activity of three TLM-loaded lipid nanoparticles (TLM-LNPs) including solid lipid nanoparticles (SLNs), nanostructured lipid carriers (NLCs) and lipid-core nanocapsu...

The transmission line method (TLM) is a very efficient method for dynamic modelling of flow in pipelines, and uses delay elements to represent wave propagation. In this paper an existing TLM model is investigated and shown to have some deficiencies. Some adjustments are proposed to avoid these deficiencies and enhance the transient and steady state accuracy. Very good agreement is obtained betw...

Management of cardiovascular risk factors in diabetes demands special attention due to their co-existence. Pioglitazone (PIO) and telmisartan (TLM) combination can be beneficial in effective control of cardiovascular complication in diabetes. In this research, we developed and validated a high throughput LC-MS/MS method for simultaneous quantitation of PIO and TLM in rat plasma. This developed ...

This paper describes a new subgridding approach with a view to improving the efficiency of full-wave simulation of electronic circuits. The proposed subgridding method has been incorporated into a full-wave variable-mesh finite-difference transmission line matrix (FD-TLM) simulator. By incorporating the proposed subgridding method, a speed-up of about 2 has been attained. The computational acce...

tilmicosin (tlm) is an important antibiotic in veterinary medicine with low bioavailability and safety. this study aimed to formulate and evaluate physicochemical properties, storage stability after lyophilization and antibacterial activity of three tlm-loaded lipid nanoparticles (tlm-lnps) including solid lipid nanoparticles (slns), nanostructured lipid carriers (nlcs) and lipid-core nanocapsu...

The Transmission Line Matrix ( TLM ) is a physical discretization approach used to solve the wave equation numerically. The method replaces a continuous system by a network or an array of lumped elements. The TLM method involves dividing the solution region into a rectangular mesh of the transmission line segments. The nodes of the mesh are the points of discontinuity for acoustic impedances. A...