BACKGROUND Tocotrienols (TCTs) are more potent antioxidants than α-tocopherol (TOC). However, the effectiveness and mechanism of the action of TCT isomers as anti-atherosclerotic agents in stimulated human endothelial cells under inflammatory conditions are not well established. AIMS 1) To compare the effects of different TCT isomers on inflammation, endothelial activation, and endothelial ni...

The intestinal absorption of tocotrienols (TCT) in dogs is, to our knowledge, so far unknown. Adult Beagle dogs (n 8) were administered a single oral dosage of a TCT-rich fraction (TRF; 40 mg/kg body weight) containing 32 % α-TCT, 2 % β-TCT, 27 % γ-TCT, 14 % δ-TCT and 25 % α-tocopherol (α-TCP). Blood was sampled at baseline (fasted), 1, 2, 3, 4, 5, 6, 8 and 12 h after supplementation. Plasma an...

Objectives: To evaluate the feasibility of oral mucosa TCT tests for early detection of lung cancer. Materials and Methods: From July 2013 to January 2014, eighty four chronic and heavy smokers with lung nodule after low-dose or plain chest computed tomography (CT) were given oral mucosa Thinprep cytological tests (TCT) and contrast-enhanced thoracic CT. Those suspected to suffer from lung tumo...

Aim: To assess the effects of sight threatening diabetic retinopathy (STDR) on colour vision and to evaluate automated tritan contrast threshold (TCT) testing for STDR screening before significant visual loss. Method: Patients were recruited from a hospital based photographic screening clinic. All subjects underwent best corrected Snellen visual acuity (BCVA) and those with 20/30 vision or wors...

AIM To assess the effects of sight threatening diabetic retinopathy (STDR) on colour vision and to evaluate automated tritan contrast threshold (TCT) testing for STDR screening before significant visual loss. METHOD Patients were recruited from a hospital based photographic screening clinic. All subjects underwent best corrected Snellen visual acuity (BCVA) and those with 20/30 vision or wors...

PURPOSE One of the main factors contributing to the accuracy of attenuation correction for SPECT imaging using transmission computed tomography (TCT) with an external gamma-ray source is the radionuclide count. To reduce deterioration of TCT images due to inadequate radionuclide counts, a correction method, segmented attenuation correction (SAC), in which TCT data are transformed into several c...

An outstanding problem in the study of vertebrate development is the identification of the genes that direct neural crest precursor cells to adopt and maintain specific differentiated cell fates. In an effort to identify such genes, we have carried out a mutagenesis screen in zebrafish and isolated mutants that lack neural crest-derived melanophores. In this manuscript we describe the phenotype...

BACKGROUND AND PURPOSE α-Tocotrienol (TCT) represents the most potent neuroprotective form of natural vitamin E that is Generally Recognized As Safe certified by the U.S. Food and Drug Administration. This work addresses a novel molecular mechanism by which α-TCT may be protective against stroke in vivo. Elevation of intracellular oxidized glutathione (GSSG) triggers neural cell death. Multidru...

AgPGRPLC-TCT complexes In the AgPGRPLC1-TCT model, the ligand conformation remained unchanged. In AgPGRPLC2-TCT small rotations of torsion angles between L-Ala and D-Glu were necessary to relieve steric clashes between the carboxyl group of D-Glu and P92. In AgPGRPLC1 and LC3 however, Pro92 is replaced by a Lys, which permits placement without a bump. Most conserved interactions are maintained ...

Bordetella pertussis releases a specific peptidoglycan fragment known as tracheal cytotoxin (TCT) that reproduces the respiratory epithelial cytopathology of whooping cough (pertussis). In vitro, TCT inhibits DNA synthesis in hamster trachea epithelial cells and causes specific destruction of ciliated cells in explants of human and hamster respiratory epithelium. We have recently demonstrated t...