the existing literature on bantu verbal semantics demonstrated that inherent semantic content of verbs pairs directly with the selection of tense, aspect and modality formatives in bantu languages like chasu, lucazi, lusamia, and shiyeyi. thus, the gist of this paper is the articulation of semantic classification of verbs in kiswahili based on the selection of tam types. this is because the sem...

The existing literature on Bantu verbal semantics demonstrated that inherent semantic content of verbs pairs directly with the selection of tense, aspect and modality formatives in Bantu languages like Chasu, Lucazi, Lusamia, and Shiyeyi. Thus, the gist of this paper is the articulation of semantic classification of verbs in Kiswahili based on the selection of TAM types. This is because the sem...

OBJECTIVES We recently reported the preferential selection of the K65R resistance mutation in subtype C HIV-1 compared with subtype B and showed the underlying mechanism to be dependent on subtype C-specific silent nucleotide polymorphisms, i.e. genomic mutations that change the genotype but not the phenotype. The number of clinical reports demonstrating elevated numbers of K65R nevertheless su...

Background: Histone deacetylation of tumor suppressor genes such as estrogen receptor alpha (ERα) can induce cancer, which is reversible by epi-drugs such as valproic acid (VPA). The previous result indicated that tamoxifen (TAM) induced apoptosis in hepatocellular carcinoma (HCC). This study was designed to assess the apoptotic and antiproliferative effects of VPA and TAM and also the ef...

It was not until the sixteenth century that dead bodies were submitted to medico-legal investigation. The horror which human dissections inspired in the ancients, and the religious awe with which they beheld the mortal wreck of their fellows, not only retarded the progress of anatomy and physiology, but excluded the light of medicine from the researches of the forum. The Jewish law, indeed, con...

The cytotoxic effect of tamoxifen (TAM) was investigated in the T-289 melanoma cell line, as well as the 289 DDP3 cisplatin (DDP)-resistant and the 289 TAM6 TAM-resistant variant melanoma cell lines to determine the effect of drug resistance on synergy. T-289 melanoma cells were made DDP or TAM resistant through chronic exposure to increasing concentrations of the respective drugs. Whereas DDP ...

The triphenylethylene antiestrogen tamoxifen (TAM) is believed to exert its antitumor effect via the estrogen receptor (ER). To test this hypothesis and to differentiate between ER-mediated and general cytotoxic effects of TAM, the growth-inhibitory effects of TAM and its in vivo metabolite 4-hydroxytamoxifen (OH-TAM) have been studied in five continuous human cancer cell lines, MCF7 and T47D (...