Background Baseline clinical variables are prognostic for overall survival (OS) in patients with castration-resistant prostate cancer (CRPC). Their prognostic and predictive value with agents targeting bone metastases, such as radium-223, is not established. Patients and methods The radium-223 ALSYMPCA trial enrolled patients with CRPC and symptomatic bone metastases. Prognostic potential of ...

Prognostic value of a bone resorption marker, tartrate-resistant acid phosphatase isoform 5b (TRACP 5b), and two matrix metalloproteinases (MMP-2 and MMP-9) was compared with the standard clinical analyses of total alkaline phosphatase (tALP) and prostate-specific antigen (PSA), in prostate cancer (PC) patients with (BM+) or without (BM-) bone metastases. Diagnostic accuracy evaluation showed t...

This paper describes the TALP phrase-based statistical machine translation system, enriched with the statistical machine reordering technique. We also report the combination of this system and the TALP-tuple, the n-gram-based statistical machine translation system. We report the results for all the tasks (Chinese, Arabic, Italian and Japanese to English) in the framework of the third evaluation...

The aim of the present investigation was to compare Tyrode’s albumin lactate pyruvate (TALP) medium and TRIS citrate medium for capacitation of caprine sperm. In experiment 1 capacitation was assessed by chlortetracycline assay and in experiment 2 with in vitro fertilization and embryo development. In experiment 2, cumulus oocyte complexes (COCs) recovered by slicing the caprine ovaries were ma...

This paper describes the experiments of the TALPUPC group for factoid and ’other’ (definitional) questions at TREC 2005 Main Question Answering (QA) task. Our current approach for factoid questions is based on a voting scheme among three QA systems: TALP-QA (our previous QA system), Sibyl (a new QA system developed at DAMA-UPC and TALP-UPC), and Aranea (a web-based data-driven approach). For de...

This paper describes the TALP-QA system in the context of the CLEF 2005 Spanish Monolingual Question Answering (QA) evaluation task. TALP-QA is a multilingual open-domain QA system that processes both factoid (normal and temporally restricted) and definition questions. The approach to factoid questions is based on in-depth NLP tools and resources to create semantic information representation. A...

BACKGROUND The purpose of this cross-sectional study was to evaluate the value of serum tartrate-resistant acid phosphatase 5b (TRACP 5b) and carboxyterminal telopeptide of type I collagen (ICTP) separately and in combination as markers of bone metastases compared to total alkaline phosphatase (tALP) in breast cancer. MATERIALS AND METHODS Two groups of patients were studied, one with verfied...

The objectives of this study were to: (i) evaluate the diagnostic sensitivity and specificity of the biochemical bone markers: serum total alkaline phosphatase (TALP), bone specific alkaline phosphatase (BSALP) and urinary deoxypyridinoline (Dpyr) in postmenopausal osteoporosis, (ii) compare the bone turnover of postmenopausal osteoporotic patients without and with hormone replacement therapy (...

Pentoxifylline (PF) is used to enhance motility of spermatozoa from infertile human subjects. We have previously shown that 0.45 mM PF improved capacitation of spermatozoa and fertilization of oocytes in vitro in hamsters. The present study was carried out to assess PF-induced changes in motility kinematics of hamster spermatozoa by a computer-aided sperm analyser (CASA) and determine the timin...

The aim of the present study was to compare a novel marker for high bone turnover with two routine markers for screening in prostate cancer patients. The markers were evaluated in two studies: (a) a cross-sectional study of 170 prostate cancer patients with local disease stratified by +/-lymph node metastases (N 0, N1) compared with controls and (b) a longitudinal study of 40 hormone refractory...