This paper introduces an experimental study of Mandarin tonal sequences produced by native English speakers. Sound recordings of learners’ Mandarin have been analyzed empirically and acoustically. The conclusions are as follows: tonal variation in accented Mandarin is not correlated to the original Mandarin tones or the context of the original Mandarin tons. The pronounced Mandarin tones select...

Thrombin binding aptamer (TBA) is a 15-mer single-strand DNA that was identified by SELEX screening technology. It adopts a chair-type antiparallel G-quadruplex and can specifically interact with thrombin, thus inhibiting blood coagulation. Isonucleoside (isoNA) is a type of nucleoside isomer in which the base is shifted to 2′-positions of the glycosyl group, endowed with the ability to modulat...

BACKGROUND Although the prevalence of esophageal cancer increases in elderly patients, its clinical history and outcome after treatment remain poorly described. METHODS Between January 2001 and December 2011, 58 patients (pts) older than 75 years received 3D-conformal radiotherapy (mean dose 51 Gy) in two French cancer centers. 47/58 (82%) patients received concomitant chemotherapy (with CDDP...

BACKGROUND Many studies have suggested different roles of Metastasis-associated protein 3 (MAT3) in different types of human cancers. However, expression of MAT3 in primary lung cancer and its relationship with clinicopathological factors have not been examined and the biological roles of MTA3 in lung cancer cells are still unclear. METHODS The expression of MAT3 mRNA and protein were detecte...

We have estimated the observed system response of STS-1 sensors installed at stations of the IRIS/IDA Seismographic Network using cross-spectral analysis of random binary calibration signals. Systematic deviations of up to 1% in amplitude and 1 ° in phase between the measured and the manufacturers "nominal" responses are observed in the range 0.2 to 100 mHz and up to 12% in amplitude and 5 ° in...