background and aims: hepatitis c virus is one of the viral infections which is mainly transmitted by blood transfusion. patients with thalassaemia frequently need blood transfusion and are in danger of hcv infection. in most cases of infection (85%) the virus evades the immune system and establishes a chronic infection that may lead to cirrhosis and liver carcinoma. liver is the main site of hc...

background and aims: hepatitis c virus is one of the viral infections transmitted by blood transfusion. patients with thalassaemia frequently need blood transfusion and are in danger of hcv infection. in most cases of infection (85%) the virus evades the immune system and establishes a chronic infection that may lead to cirrhosis and liver carcinoma. liver is the main site of hcv replication hc...

background: nowadays, the immune response to hepatitis c (hcv) treatment has become a crucial issue mostly due to the interleukin 28b (il-28b) polymorphism effects in chronic hcv patients. the aim of this study was to detect the polymorphism of il-28b gene (rs12979860) in hcv genotype 1 patients treated with pegylated interferon and ribavirin. methods: from the 2010 to 2012, a total of 115 peri...

Introduction: The aim of this study is to assess the therapeutic efficacy and safety of a particular brand of IFN alpha (PDferon B®) in combination with ribavirin (RlBA) on Iranian patients with chronic hepatitis C (CHC). The addition of RIBA to the standard treatment with interferon (IFN) alpha led to an improvement in sustained virologic response (SVR) from less than 20% with IFN monother...

aim : the aim of study was to determine the preliminary result of treatment with pegasys in iranian chronic hepatitis b patients (with genotype d) referred to tehran hepatitis center (thc). background : the genotype of hbv and ethnicity of the patients can affect the response rate to pegasys. patients and methods : during 2006-2008, 12 patients with naïve chronic hepatitis b (genotype d) that r...

introduction: the aim of this study is to assess the therapeutic efficacy and safety of a particular brand of ifn alpha (pdferon b®) in combination with ribavirin (rlba) on iranian patients with chronic hepatitis c (chc). the addition of riba to the standard treatment with interferon (ifn) alpha led to an improvement in sustained virologic response (svr) from less than 20% with ifn monotherapy ...

BACKGROUND Clinical outcomes of chronic hepatitis C infection in patients with advanced fibrosis include liver failure, hepatocellular carcinoma, and death. OBJECTIVE To investigate whether sustained virologic response to treatment for hepatitis C is associated with improved clinical outcomes. DESIGN Retrospective cohort study. SETTING 5 hepatology units of tertiary care centers in Europe...

BACKGROUND Patients infected with hepatitis C virus (HCV) genotype 2 or 3 have sustained virologic response rates of approximately 80% after receiving treatment with peginterferon and ribavirin for 24 weeks. We conducted a large, randomized, multinational, noninferiority trial to determine whether similar efficacy could be achieved with only 16 weeks of treatment with peginterferon alfa-2a and ...

BACKGROUND The standard treatment of chronic hepatitis C is the administration of pegylated interferon α2a or α2b in combination with ribavirin, but adverse effects can be observed, as well as the high cost of this therapy. Therefore, there is interest in understanding the predictors of sustained virologic response, as the gamma glutamyltransferase. OBJECTIVE To evaluate the serum levels of g...