To achieve successful delivery of drug locally as well as systematically rectal route has proved its potential. The main objective of this research work was to evaluate the in vivo performance of paracetamol Suppocire CP suppository. Initially, suppositories were prepared, evaluated for their physicochemical parameters and in vitro drug release. An in vivo investigation of paracetamol availabil...

OBJECTIVE To compare the efficacy of glycerin suppository versus no suppository in preterm very-low-birthweight neonates for improving feeding tolerance. DESIGN Randomized controlled trial. SETTING Level III neonatal unit from Mumbai, India. PARTICIPANTS 50 very-low-birthweight (birth weight between 1000 to 1500 grams)preterm (gestational age between 28 to 32 weeks) neonates randomized to...

The objective of this study was to develop vaginal suppository containing lactobacillus. Four kinds of vaginal suppositories containing Lactobacillus paracasei HL32 were formulated: 1) a conventional suppository with Witepsol H-15 as a base, 2) a conventional suppository with mixed polyethylene glycols (PEGs) as a base, 3) a hollow-type suppository with Witepsol H-15 as a base and 4) a hollow-t...

Goreisan suppository is prepared as a hospital preparation, and successfully used for the treatment of diarrhea and vomiting in young children with common cold. While clinical efficacy of the suppository has been reported, few studies have been carried out to clarify the preparation procedure and pharmacokinetics of the suppository. In this study, trans-cinnamic acid (CA) was used as a represen...

suffering from febrile convulsions. Previous studies of clinical applications of rectal DZP have shown that intermittent administration of DZP suppositories during the febrile period prevents recurrent febrile convulsions. In addition to DZP suppository, acetaminophen (AAP) suppositories are occasionally used to ease suffering by high fever. However, the simultaneous combination of DZP and AAP ...

A traditional Chinese herbal medicine, Kampo medicine, maoto, has been widely used in the treatment of febrile symptoms caused by viral infection. This herbal extract granule for oral use, however, is not well accepted by infants or young children due to its unpleasant taste and odor. Therefore, we prepared Kampo medicine, maoto, suppository and investigated the pharmaceutical and clinical effi...

Introduction: Parikartika is most common ano-rectal disorder. The text of parikartika mentioned in Samhitas. In this disease there are symptoms such as bleeding per rectum, hard stools, burning sensation around anal region. trial, group A (n=30) included Palashadigudavarti, whereas B Diclofenac sodium suppository for administration over (acute fissures). Gandharva haritaki choorna acts laxative...

This study investigated efficacy and side effects of Morphine suppository for pain management after the first elective caesarean delivery in comparison to Diclofenac suppository. One hundred women aged 18-40 with term pregnancies undergoing elective caesarean section for the first time participated in this prospective project. Exclusion criteria included drug sensitivity, fetal malformations or...

Purpose: To use differential scanning calorimetry (DSC) to predict the liquefaction time and dissolution profile of some commercial paracetamol suppositories as well as paracetamol suppositories formulated with palm oil base. Methods: The suppository base was prepared by mixing hydrogenated palm oil and palm kernel stearin in a ratio of 8:2. Three commercial paracetamol suppositories (A, B, and...

Astragalus polysaccharide (APS) (used for intestinal protection) was added to formulate the Tongshu suppository to improve the pharmacokinetics of Aceclofenac, which were assessed in New Zealand rabbits using an orthogonal experimental design. The single-agent Aceclofenac was taken as the control formulation. The concentration-time and drug release curves were drawn, and T max (min), C max (μg·...