the supersaturatable self-microemulsifying drug delivery system (s-smedds) represents a new thermodynamically stable formulation approach wherein it is designed to contain a reduced amount of surfactant and a water-soluble polymer (precipitation inhibitor or supersaturated promoter) to prevent precipitation of the drug by generating and maintaining a supersaturated state in-vivo. the supersatur...

The supersaturatable self-microemulsifying drug delivery system (S-SMEDDS) represents a new thermodynamically stable formulation approach wherein it is designed to contain a reduced amount of surfactant and a water-soluble polymer (precipitation inhibitor or supersaturated promoter) to prevent precipitation of the drug by generating and maintaining a supersaturated state in-vivo. The supersatur...

The supersaturatable self-microemulsifying drug delivery system (S-SMEDDS) represents a new thermodynamically stable formulation approach wherein it is designed to contain a reduced amount of surfactant and a water-soluble polymer (precipitation inhibitor or supersaturated promoter) to prevent precipitation of the drug by generating and maintaining a supersaturated state in-vivo. The supersatur...

Spray dried dispersions (SDDs) of glipizide, a BCS Class II model drug, were prepared using various grades of hydroxypropyl methylcellulose acetate succinate (HPMCAS) and copovidone S-630 as carriers. The SDDs appeared as a single amorphous phase with up to 60% drug loading level as revealed by X-ray powder diffraction (XRPD), modulated differential scanning calorimetry (mDSC) and scanning elec...

Supersaturated design is an important aspect of experimental design. Several properties of supersaturated designs have been obtained that enable supersaturated design to be constructed while maintaining low dependency over all pairs of columns. This paper presents generalized theorems on the optimality of supersaturated designs. Mixed-level supersaturated designs are generated using a construct...

Dissolved inert gas measurements in the ocean yield important information about processes that occur during water mass formation. We present argon, nitrogen, and neon data from the subtropical and subpolar North Pacific and the subtropical North Atlantic. All three gases were supersaturated at the surface. In the deep ocean, Ar and N2 were undersaturated while Ne remained supersaturated. All th...

Supersaturation of a solution system is a metastable state containing more solute than can be normally solubilized. Moreover, this condition is thermodynamically important for a system undergoing a phase transition. This state plays critical roles in deposition morphology in inorganic, organic, polymer and protein solution systems. In particular, microscopic solution states under supersaturated...

Hadamard matrices are found to be useful in constructing supersaturated designs. In this paper, we study a special form of supersaturated designs using Hadamard matrices. Properties of such a supersaturated design are discussed. It is shown that the popular E(s) criterion is in general inadequate to measure the goodness of a supersaturated design. A new criterion based upon the projection prope...

poor skin penetration. To improve the cutaneous absorption of drugs, various methods have been developed such as chemical penetration enhancers, novel vehicle systems and physical enhancement techniques including iontophoresis, sonophoresis, and electroporation. Supersaturated formulations are one of the vehicle systems, and its potential benefit has been examined by many investigators. Supersa...