cancer is considered as a challenging deathly disease and discovering or synthesis of new cytotoxic agents is a worldwide attempt. in this study, a group of recently synthesized chalcones, with the structure of 1,3-diarylprop-2-en-1-one having differesnt cox-1 and/or cox-2 selectivities, have been examined on human hepatocarcinoma (hepg2), lung carcinoma (a549), and breast adenocarcinoma (mcf-7...

Brain pathologies, including stroke and tumors, are associated with a variable degree of breakdown of the blood-brain barrier (BBB), which can usefully be studied in animal models. We describe a new optical technique for quantifying extravasation in the cortex of the living mouse and for imaging intraparenchymal tissue. Leakiness of the BBB was induced by microbeam x-irradiation. Two fluorescen...

The optical properties of sulforhodamine B (SRB) hosted in surfactant-modified layered double hydroxide (LDH) are explored using quantum yield efficiencies and temporal variations luminescence. effect the spacer,...

We examined endothelin-1 (ET-1) regulation of the xenobiotic efflux pump, multidrug resistance-associated protein isoform 2 (MRP2), in intact dogfish shark rectal salt gland tubules using a fluorescent substrate sulforhodamine 101 and confocal microscopy. Subnanomolar to nanomolar concentrations of ET-1 rapidly reduced the cell-to-lumen transport of sulforhodamine 101. These effects were preven...

We perform an optical study of sulforhodamine B and sulforhodamine 101 molecules solved in water droplets ~reversed micelles! that are stabilized by a surfactant and suspended in various mixtures of heptane and toluene. While the dielectric permittivity of the surrounding medium varies with the proportions of heptane and toluene, the chemical environment of the dye molecules always remains the ...

In conjunction with quenching metal ions, silica nanoparticles carrying terpyridine coordination sites and sulforhodamine B signalling units were employed for the differential fluorometric recognition of anions.

We demonstrate a strong coupling between surface plasmon polaritons and Sulforhodamine 101 dye molecules. Dispersion curves for surface plasmon polaritons on samples with a thin layer of silver covered with Sulforhodamine 101 molecules embedded in SU-8 polymer are obtained experimentally by reflectometry measurements and compared to the dispersion of samples without molecules. Clear Rabi splitt...