In this work the antibacterial activity of asulfathiazole derivative was evaluated against both Staphylococcus aureus and Vibrio cholerae using cefotaxime, gentamicin, ciprofloxacin and sulfathiazole as controls. The evaluation of antimicrobial effect of the different compounds on the bacterial species was made by the method of microbial minimal inhibitory. The results indicate that bacterial g...

A sulfathiazole-resistant dihydropteroate synthase (DHPS) present in two different laboratory strains of Escherichia coli repeatedly selected for sulfathiazole resistance was mapped to folP by P1 transduction. The folP mutation in each of the strains was shown to be identical by nucleotide sequence analysis. A single C-->T transition resulted in a Pro-->Ser substitution at amino acid position 6...

The sulfonamide derivatives differ from compound to compound not only in scope and effectiveness of chemotherapeutic action4 but also in their pharmacological properties."8 It becomes important, therefore, with each new compound introduced, after preliminary studies in animals, to determine the facts concerning these properties in man. In this paper are recorded observations in man on the absor...

Long and Bliss,20 and Mellon, Gross, and Cooper,24 in their monographs, have reviewed the conflicting evidence on the action of sulfanilamide, neoprontosil, and other early derivatives which have not found satisfactory clinical application. The reported experimental work on the action of sulfapyridine, sulfathiazole, and sulfamethylthiazole has held out greater promise of success against the st...

Pharmaceutical co-crystallisation is emerging as a possible alternative to polymorphs, salts and solvates in the modification of an active pharmaceutical ingredient (API) during dosage form. It may alter the physico-chemical properties of the API (e.g. melting point and solubility), and also have intellectual property implications. Traditionally, co-crystallisation research has involved robust ...

template synthesis is a powerful method for the preparation of nanoscale materials with specific size and shape. cadmium oxide (cdo) nanoparticles were synthesized by using sodium dodecyl sulfate (sds), cd(oac)2.2h2o and sodium hydroxide as starting materials. the sample was characterized by x-ray diffraction (xrd), scanning electron microscopy (sem). the xrd pattern proves that the final produ...

Studies by Feinstone, Williams, Wolff, Huntington, and Crossley4 on the toxicity, absorption, and chemotherapeutic activity of this compound in mice, dogs, and monkeys indicate that it exhibits less acute and chronic toxicity than either sulfapyridine or sulfathiazole. In addition, these investigators found sulfadiazine to be readily absorbed, eliminated comparatively slowly, and acetylated to ...