Veterinary antibiotics in groundwater may affect natural microbial denitrification process. A microcosm study was conducted to evaluate the influence of sulfamethazine and chlortetracycline at different concentrations (0, 0.01, 0.1, and 1.0 mg/L) on nitrate reduction in groundwater under denitrifying condition. Decrease in nitrate removal and nitrite production was observed with the antibiotics...

Sulfamethazine acetylation phenotype was determined in 49 patients with cancer of the colon or rectum, 41 old, and 45 young control subjects. Metabolic clearance of sulfamethazine, plasma ratio of Af-acetylsulfamethazine:/V-acetylsulfamethazine plus sulfamethazine and urinary ratio of A/-acetyIsulfamethazine:Ar-acetylsulfamethazine plus sulfamethazine were used to classify subjects into slow an...

Batch sorption of sulfamethazine was conducted using five soils with organic carbon (OC) contents ranging from 0.1% to 3.8% and solution pHs ranging from 5.5 to 9. Sorption of sulfamethazine was found to be impacted by OC, soil surface area and soil solution pH, with higher K(d) values for soils with higher OC and lower K(d) values as the pH increased. However, OC was found to be the more domin...

Land application of manure containing antimicrobials results in the dispersion of the antimicrobials in agro-ecosystems. Dissipation of excreted antimicrobials in seasonally frozen agricultural soils has not been fully characterized under field conditions. This study investigated the field dissipation kinetics of chlortetracycline, sulfamethazine, and tylosin over a 10-mo period after fall appl...

A liquid chromatographic tandem mass spectrometric method for the determination of sulfa drugs in beeswax was developed. When performing residue control on beeswax intended for the fabrication of wax foundations, residues of sulfonamides were found. A migration test was set up to study whether sulfonamide-containing beeswax could lead to the contamination of honey. The higher the concentration ...

Surface water samples from downstream and estuarine areas of Jiulong River were collected in August 2011 and May 2012 for detecting sulfonamide antibiotic residues and isolating sulfamethazine-resistant bacteria. Sulfamethazine was detected in all samples in May 2012 at an average concentration of 78.3 ng L(-1), which was the highest among the nine sulfonamide antibiotics determined. Sulfametha...

A Bacillus stearothermophilus var. calidolactis C953 tube test was evaluated for its ability in detecting the residue of selected anticoccidial drugs in poultry, specially sulfamethazine, furazolidone, and amprolium. Various concentrations of each drug were injected into chicken liver and kidney tissues and these tissues were tested to determine the drug detection limits for each drug. The dete...

C HLORTETRACYCLINE is well established as an additive used extensively in swine rations to aid in the prevention of losses from enteritis (Braude et al., 1953; Jukes, 1955), cervical abscesses (Gouge et al., 1957, 1958), atrophic rhinitis (Gouge et al., 1956; Elliott, 1957), and for increasing body weight gains and improving feed efficiency (Beeson and Conrad, 1955; Catron, 1961; Elliott et al....

The potential impact of six antibiotics (chlortetracycline, tetracycline and tylosin; sulfamethoxazole, sulfamethazine and trimethoprim) on plant growth and soil quality was studied by using seed germination test on filter paper and plant growth test in soil, soil respiration and phosphatase activity tests. The phytotoxic effects varied between the antibiotics and between plant species (sweet o...

A monoclonal antibody (mab) against the antimicrobial sulfamethazine was prepared and characterized by an indirect competitive enzyme-linked immunosorbent assay (IC-ELISA). Sulfamethazine in the range of 0.2 and 45 ng/ml could be determined with the mab by IC-ELISA. cDNAs encoding a variable heavy chain and variable light chain of the mab were cloned to produce recombinant antibodies using phag...