INTRODUCTION Sulfacetamide sodium is a widely used sulfonamide for ophthalmic infections. OBJECTIVE A number of analytical methods have been reported for the analysis of sulfacetamide but they lack the ability to determine both the active drug and its major degradation product, sulfanilamide, simultaneously in a sample. MATERIALS AND METHODS In the present study a simple, rapid and economic...

Sodium sulfacetamide is effective in the management of a variety of inflammatory facial dermatoses and often is used in combination with sulfur for a synergistic effect. Adverse effects from sodium sulfacetamide are rare and generally are limited to mild application-site reactions. This agent is contraindicated in any patient with known hypersensitivity to sulfonamides.

A new Kinetic Spectrophotometic method for the Determination of trace amount Sulfacetamide Drug into real samples has been described based with silver nanoparticles starch-capped sensor, by sodium borohydride. The reaction is followed spectrophotometrically by measuring the decrease in the absorbance at 347.5 nm. 1.0×10-2 molL-1 silver nanoparticles starch-capped sensor, 2.0×10-3 mol L-1 sodium...

Antibiotics as additives in animal feedstuffs are forbidden in many countries in the world, but they are still abused. A micellar electrokinetic capillary chromatography method was performed at 25 C and 30 kV (under pressure 15 mbar) using 25 mmol dm phosphate buffer (pH = 8.0) containing 70 mmol dm sodium dodecysulfate (SDS) and 10 % (volume fraction) methanol as the background electrolyte fo...

The effects of exogenous abscisic acid (ABA) and its two agonists, Sulfacetamide (Sa) and Sulfasalazine (SS) on tolerance of tomato (Lycopersicon esculentum Mill. Cv. Super chief) under drought stress were studied. Eight-week plants were treated with ABA (25 and 50 mg/L), Sulfacetamide (Sa) (25, 50 and 100 mg/L) and Sulfasalazine (SS) (25, 50 and 100 mg/L). Solutions were sprayed daily and samp...

Both cytotoxic and invasive strains of Pseudomonas aeruginosa can damage corneal epithelial cells in vitro, but neither can infect healthy corneas in vivo. We tested the hypothesis that whole human tear fluid can protect corneal epithelia against P. aeruginosa virulence mechanisms. Cultured corneal epithelial cells were inoculated with 10(6) CFU of one of 10 strains of P. aeruginosa (five cytot...

It is well known that the incorporation of wetting agents in drug solutions for local application enhances the penetration of the drug into the tissues (McKee et al., 1943; Bellows and Gutman, 1943; Trim and Alexander, 1946). Ginsburg and Robson (1945) have shown that when dodecyl sodium sulphate is incorporated in solutions of sodium sulphacetamide applied to the cornea, the increase in penetr...

this work. We are also indebted to the " W. H. Ross Foundation (Scotland) for the Prevention of Blindness," who have defrayed the expenses of this investigation; to Sir Henry Dale, who kindly gave us some of his supply of tyrothricin; to Dr. Trevan, of the Weilcome Research Foundation, who kindly supplied us with penicillin made by Dr. Pope and Miss Stevens; and to Mr. Edwards, of British Scher...

Successful management of acne requires careful patient evaluation followed by consideration of several patient and medication factors when selecting a particular therapeutic regimen. Within the last few years, several new agents for the treatment of acne have become available that afford greater flexibility in the treatment of this prevalent dermatologic disorder. These include adapalene, tazar...