Cordyceps militaris produces cordycepin, which is known to be a bioactive compound. Currently, cordycepin hyperproduction of C. militaris was carried out in a liquid surface culture because of its low productivity in a submerged culture, however the reason was not known. In this study, 4.92 g/L of cordycepin was produced at the 15th day of C. militaris NBRC 103752 liquid surface culture, but on...

The growth kinetics of Aspergillus nidulans, Mucor hiemalis and Penicillium chrysogenum on solid media and in submerged culture were studied. Growth of A. nidulans colonies on solid medium can be divided into the four phases of lag, exponential, deceleration and constant growth rate. The growth kinetics of A. nidulans in submerged culture were similar to those commonly found for unicellular mic...

Performance of Cordyceps militaris mutant obtained by high-energy ion beam irradiation regarding anti-cancer agent cordycepin production in submerged culture was investigated. It was established that the mutant renders a higher production performance in surface liquid culture, needs to observe its performance in submerged culture. Two kinds of media were used for submerged culture comprising a ...

We investigated the anticancer effects of Antrodia cinnamomea, a medicinal mushroom from Taiwan, on A549 human lung cancer cells using the ethyl acetate extract from submerged culture filtrates. Our results showed that 2,3-dimethoxy-5-methyl-1,4-benzoquinone (coenzyme Q0; CoQ0) derived from A. cinnamomea submerged culture filtrates has anticancer activity. CoQ0 treatment reduced the viability o...

: world population has been continuously raised and therefore due to this fact new source of foods, particularly proteins, are in demand. in recent years, single cell protein has been considered as an accepted substitute for animal and plant proteins. in this study, single cell protein production was studied in a batch submerged culture using aspergillus niger ptcc5012. experimental design was ...

There has been a steady increase in the consumption of citric acid during the past 25 years. An estimate by Cochrane (1948) places annual manufacture at approximately 35 million pounds. Commercial production of citric acid is reputedly based on fermentation by Aspergillus niger of a suitable grade of beet syrup in shallow pans. A submerged process appears to be highly desirable, and many articl...

A wild-type strain of Streptomyces griseus forms spores both on solid media (aerial spores) and in liquid culture (submerged spores). Both spore types are highly resistant to sonication, but only aerial spores are resistant to lysozyme digestion. Electron micrographs suggest that lysozyme sensitivity may result from the thinner walls of the submerged spores. Studies of the life cycle indicate t...