stress-related mucosal damage (srmd) is a significant cause of morbidity and mortality in critically ill patients due to the gastrointestinal blood loss. prophylaxis of srmd with proton pump inhibitors or histamine-2 blockers has gained widespread use in intensive care units. both demonstrated to be effective in reducing clinically significant bleedings, while ppis has shown to exert some anti ...

BACKGROUND The term stress-related mucosal disease (SRMD) represents a continuum of conditions ranging from stress-related injury (superficial mucosal damage) to stress ulcers (focal deep mucosal damage). Caused by mucosal ischemia, SRMD is most commonly seen in critically ill patients in the intensive care unit (ICU). Prophylaxis of stress ulcers may reduce major bleeding but has not yet been ...

background: ventilator-associated pneumonia (vap) increases the cost of intensive care unit (icu) treatment and the chance of mortality. due to the increasing use of proton pump inhibitors (ppi) and h2 receptor inhibitors for stress ulcer prophylaxis, the purpose of the study was to investigate the differences of vap in two groups of patients receiving ppi or h2 blocker. methods: in the retrosp...

Stress-related mucosal damage (SRMD) is a significant cause of morbidity and mortality in critically ill patients due to the gastrointestinal blood loss. Prophylaxis of SRMD with proton pump inhibitors or histamine-2 blockers has gained widespread use in intensive care units. Both demonstrated to be effective in reducing clinically significant bleedings, while PPIs has shown to exert some anti ...

Stress-related mucosal damage (SRMD) is a significant cause of morbidity and mortality in critically ill patients due to the gastrointestinal blood loss. Prophylaxis of SRMD with proton pump inhibitors or histamine-2 blockers has gained widespread use in intensive care units. Both demonstrated to be effective in reducing clinically significant bleedings, while PPIs has shown to exert some anti ...

BACKGROUND Upper gastrointestinal bleeding is the severe complication of stress-related mucosal disease in hospitalized patients. In intensive care units (ICU), risk factors are well defined and only mechanical ventilation and coagulopathy proved to be relevant for significant bleeding. On the contrary, in non-ICU settings there is no consensus about this issue. Nevertheless, omeprazole is stil...

in this study the effect of nitric oxide synthesis inhibition on stress-induced gastric damage was evaluated in bile duel ligated, sham operated and unoperated rats. animals were injected intraperitoneally with ng-nitro-l-arginine methylester (l-name), 40 mglkg, l-argininc, 200 mg/kg or saline, 30 min before water-immersion stress. one hour after water immersion, the animals were killed and the...