The aim of the work is to identify strains streptomycetes in genomes which there are nucleotide sequences similar gene cluster determining synthesis landomycin A (lan-cluster) and establish level similarity their primary structures organizations. Methods. Information on lan-cluster Streptomyces cyanogenus S136 chromosomal DNAs S. S136, laculatispora NRRL B-24909, griseoluteus JCM 4765 annotatio...

Colonies of streptomycetes are now viewed as multicellular entities containing morphologically and biochemically differentiated cell types which have specific functions and precise spatial relationships to one another. Like multicellular organisms, colony development in streptomycetes is also maintained by a tight balance between cell proliferation and cell death processes. This review describe...

Abstract Streptomycetes have to cope with fluctuating nitrogen conditions in soil. Key enzymes metabolism streptomycetes are the two glutamine synthetases (GSs), GlnA and GlnII. We demonstrated that GlnA3 GlnA4, proteins previously annotated as GSs, involved utilization detoxification of polyamines ethanolamine. Homologs these present pathogenic Actinobacteria promising drug targets. designed a...

Over 200 genomes of streptomycete strains that were isolated from various environments are available from the NCBI. However, little is known about the characteristics that are linked to marine adaptation in marine-derived streptomycetes. The particularity and complexity of the marine environment suggest that marine streptomycetes are genetically diverse. Here, we sequenced nine strains from the...

In addition to mold, indoor bioaerosols also contain bacterial components that may have implications for human health. Endotoxin is a cell wall component in Gram-negative bacteria present at varying levels indoors that has been found to have respiratory health implications. Streptomyces is a large genus of Gram-positive bacteria, and some species have been shown to produce inflammatory reaction...

The Streptomyces populations inhabiting five acidic forest soils were examined. It was found that lowering the pH of a medium selective for streptomycetes (starch-casein agar) to the pH of the particular soil horizon being plated influenced both the total numbers and types of streptomycetes that were isolated from the soils examined in this study. On the acidified medium both the numbers of str...

Almost complete sequences of the 16s rRNA genes of eight representative thermophilic streptomycetes were determined following the isolation and cloning of the amplified genes. These sequences were aligned with those of representative mesophilic streptomycetes, and phylogenetic trees were inferred by using four tree-making algorithms. The thermophilic streptomycetes formed two distinct clades th...

Streptomycetes produce useful enzymes and a wide variety of secondary metabolites with potent biological activities (e.g., antibiotics, immunosuppressors, pesticides, etc.). Despite their importance in the pharmaceutical and agrochemical fields, there have been no reports for practical expression systems in streptomycetes. Here, we developed a "P(nitA)-NitR" system for regulatory gene expressio...