نتایج جستجو برای: Spiramycin

تعداد نتایج: 293  

Journal: :Antimicrobial agents and chemotherapy 2007
Xianbin Tian Jun Li Maciej J Zamek-Gliszczynski Arlene S Bridges Peijin Zhang Nita J Patel Thomas J Raub Gary M Pollack Kim L R Brouwer

The multidrug resistance proteins P-glycoprotein (P-gp), breast cancer resistance protein (Bcrp), and multidrug resistance-associated protein 2 (Mrp2) are the three major canalicular transport proteins responsible for the biliary excretion of most drugs and metabolites. Previous in vitro studies demonstrated that P-gp transported macrolide antibiotics, including spiramycin, which is eliminated ...

Journal: :Antimicrobial agents and chemotherapy 1983
T C Quee T Roussou E C Chan

The minimal inhibitory concentrations of Rodogyl (composite tablet of metronidazole and spiramycin), metronidazole-spiramycin mixture, spiramycin, metronidazole, and tetracycline were determined for selected putative periodontopathic microorganisms. Rodogyl was active against almost all strains, including Bacteroides species and the anaerobic spirochetes. Synergism of the component drugs in the...

2016
Mun Ock Kim Hyung Won Ryu Ji-Hee Choi Tae Hyun Son Sei-Ryang Oh Hyun-Sun Lee Heung Joo Yuk Sungchan Cho Jong Soon Kang Chang Woo Lee Jinhyuk Lee Chong-Kil Lee Sung-Tae Hong Su Ui Lee

The effects of spiramycin on adipogenesis and high fat diet (HFD)-induced obesity were investigated. Potential mechanisms contributing to these effects were elucidated. The inhibitory effect of spiramycin on adipocyte differentiation was assessed using 3T3-L1 preadipocyte cells, in which several parameters involved in AMPK signal pathways and lipid metabolism were examined. To further investiga...

Journal: :British journal of clinical pharmacology 1989
M Kessler P Netter H E Renoul P Trechot B Dousset B Bannwarth

1. The influence of spiramycin coadministration on cyclosporin pharmacokinetics was studied in five renal transplant patients. The plasma concentrations of cyclosporin were measured both by non-specific radioimmunoassay (RIA) and high-performance liquid chromatography (h.p.l.c.). 2. The kinetics of cyclosporin were followed before treatment, and after 1 day and then 2 weeks of oral treatment wi...

Journal: :Microbiology 2007
Fatma Karray Emmanuelle Darbon Nathalie Oestreicher Hélène Dominguez Karine Tuphile Josette Gagnat Marie-Hélène Blondelet-Rouault Claude Gerbaud Jean-Luc Pernodet

Spiramycin, a 16-membered macrolide antibiotic used in human medicine, is produced by Streptomyces ambofaciens; it comprises a polyketide lactone, platenolide, to which three deoxyhexose sugars are attached. In order to characterize the gene cluster governing the biosynthesis of spiramycin, several overlapping cosmids were isolated from an S. ambofaciens gene library, by hybridization with vari...

Journal: :Revista da Associacao Medica Brasileira 2015
Wanderley Marques Bernardo Miriam Chinzon Felipe Galvão Batista Chaves

result The combined search strategies led to the retrieval of 224 studies. After applying the eligibility criteria, based on titles and abstracts, 9 studies1-9 were selected for critical evaluation of texts. Of the studies, 8 were observational cohorts (7 historical and one prospective) and one systematic review. Patients included in the evidence were pregnant women with acute toxoplasmosis tre...

2015
Alpaslan Tanoglu Eylem Cagiltay Yavuz Beyazit

So far, spiramycin-associated acute pancreatitis has not been reported in literature. In this letter, it was presented that A 63-year-old female subject was experienced acute pancreatitis 4 days after taking spiramycin for therapy of dental infection, as an unusual approach. She was prescribed spiramycin tablet for dental infection, and in 4th day, she admitted to emergency service with severe ...

Journal: :Antimicrobial agents and chemotherapy 1994
E Schoondermark-Van de Ven J Galama W Camps T Vree F Russel J Meuwissen W Melchers

Transplacental transfer of spiramycin was investigated in a rhesus monkey model to study whether the antibiotic reaches therapeutic levels in the fetus. Spiramycin concentrations were measured by bioassay and high-performance liquid chromatography. Pharmacokinetic parameters were determined for bioactive spiramycin as measured by the bioassay. Pharmacokinetic pilot studies showed that spiramyci...

2016
Xiaonan Zhang Xia Wu Fengying Xie Zhongjiang Wang Xiuling Zhang Alan X. Wang

Due to its low bioavailability and slow dissolution rate, the micronized spiramycin powder was thus prepared by the homogenate-antisolvent precipitation (HAP) process. The optimum micronization conditions of the HAP process were found to be as follows: precipitation temperature of 4.6 ◦C, precipitation time of 10 min, spiramycin concentration of 20 mg/mL, dripping speed of the added solvent int...

Journal: :Journal of Zhejiang University. Science 2004
Zhi-hua Jin Pei-lin Cen

Strain improvement and medium optimization to increase the productivity of spiramycin were carried out. Of oil tolerant mutant strains screened, one mutant, Streptomyces ambofaciens XC 2-37, produced 9% more spiramycin than the parent strain S. ambofaciens XC 1-29. The effects of soybean oil and propyl alcohol on spiramycin production with S. ambofaciens XC 2-37 were studied. The potency of S. ...

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