in this study organotypic adult spinal cord slices were used to investigate whether caspases could participate in the apoptosis of motor neurons. the thoracic region of spinal cord was sliced using a tissue chopper and cultured in a medium for 6h. morphological and biochemical features of apoptosis were assessed by fluorescent staining and terminal deoxynucleotidyl nick end labeling (tunel) met...

during the last few decades, focus of rehabilitation outcome has been redirected to the lifetime monitoring of quality of life. the purpose of this study was to investigate the differences in quality of life perceptions between participants with spinal cord injury and participants of typical population.this cross-sectional controlled study of 100 adults aged 18-65 years was based on two questio...

BACKGROUND/AIMS Childhood cerebral palsy (CP) is associated with osteopenia and the GH-IGF axis plays an important role in bone metabolism. We studied the relationship between spinal bone mineral density (BMD) and serum IGF-1 and IGFBP-3 in children with CP. METHODS Cross-sectional study of 30 children (9 F and 21 M, ages 4.5-15) with CP. Subjects underwent dual-energy x-ray absorptiometry sc...

BACKGROUND In patients with chronic spinal cord injury, imaging of the spinal cord and brain above the level of the lesion provides evidence of neural degeneration; however, the spatial and temporal patterns of progression and their relation to clinical outcomes are uncertain. New interventions targeting acute spinal cord injury have entered clinical trials but neuroimaging outcomes as responsi...

STUDY DESIGN A blinded, randomized controlled trial was conducted. OBJECTIVE To test the hypothesis that chiropractic side-posture manipulation (adjusting) of the lumbar spine separates (gaps) the zygapophysial (Z) joints. SUMMARY OF BACKGROUND DATA Spinal adjusting is thought to gap the Z joints, yet no studies have conclusively validated this hypothesis, and some investigators have report...

1 2 A mixed Ca2+ channel blocker, A-1264087, utilizes peripheral and spinal 3 mechanisms to inhibit spinal nociceptive transmission in a rat model of 4 neuropathic pain 5 6 Jun Xu, Katharine L. Chu, Chang Z. Zhu, Wende Niforatos, Andrew Swensen, Xenia 7 Searle, Lance Lee, Michael F. Jarvis, and Steve McGaraughty* 8 9 Neuroscience Research, AbbVie, 1 North Waukegan Road, North Chicago, IL, 60064...

In this study organotypic adult spinal cord slices were used to investigate whether caspases could participate in the apoptosis of motor neurons. The thoracic region of spinal cord was sliced using a tissue chopper and cultured in a medium for 6h. Morphological and biochemical features of apoptosis were assessed by fluorescent staining and terminal deoxynucleotidyl nick end labeling (TUNEL) met...