metformin hydrochloride (mfh) is an oral anti-diabetic drug of biguanide class. two selective spectrophotometric methods were presented for the determination of mfh in pharmaceuticals. the methods were based on the measurement of yellow-coloured charge-transfer complexes formed between mfh and two poly-nitrophenols, namely, 2,4-dinitrophenol (dnp method, at 405 nm) and picric acid (pa method; a...

Due to the presence of PCR inhibitors, PCR cannot be used directly on most clinical samples, including human urine, without pre-treatment. A magnetic bead-based strategy is one potential method to collect biomarkers from urine samples and separate the biomarkers from PCR inhibitors. In this report, a 1 mL urine sample was mixed within the bulb of a transfer pipette containing lyophilized nuclei...

a new method was developed for the spectral resolution by further determination of three- and  four-component  mixtures  of  drugs in urine samples through  the complementary application of multivariate curve resolution-alternating least squares with correlation  constraint. in the current study, a simple method was proposed to construct a calibration set for the mixture of drugs in the presenc...

      A new method was developed for the spectral resolution by further determination of three- and  four-component  mixtures  of  drugs in urine samples through  the complementary application of multivariate curve resolution-alternating least squares with correlation  constraint. In the current study, a simple method was proposed to construct a calibration set for the mixture of drugs in the p...

Mycobacterial pathogens can be excreted in human urine by some infected individuals. High numbers of pathogenic mycobacteria in the urine could represent a new transmission route for mycobacterial infections if the urine is used for crop fertilization. In this study, the survival of spiked Mycobacterium aurum and M. fortuitum as fast-growing mycobacteria and M. avium and M. bovis as slow-growin...

The electrochemical oxidation of labetalol was investigated by cyclic, linear sweep and differential pulse voltammetry at carbon paste electrode in Britton—Robinson buffers over the pH range 2.0—10.0. For analytical purposes, a well-defined adsorption-controlled anodic peak was obtained in Britton—Robinson buffer at pH 2.0. By anodic adsorptive linear sweep and differential pulse voltammetry, l...

In this communication, we molecularly engineered a light-switching excimer oligonucleotide-based probe for time-resolved fluorescent detection of Hg(2+). By combining a time-resolved fluorescence technique and magnetic nanoparticles, Hg(2+) spiked in human urine was detected.

The electrochemical reduction of zanosar was investigated systematically by direct current polarography, cyclic voltammetry, and differential pulse polarography (DPP). A simple DPP technique was proposed for the direct quantitative determination of anticancer drug zanosar in pharmaceutical formulation and spiked human urine samples for the first time. The reduction potential was -0.28 V versus ...

Two simple, rapid, cost-effective and sensitive spectrophotometric procedures are proposed for the determination of hydroxyzine dihydrochloride (HDH) in pharmaceuticals and in spiked human urine. The methods are based on the charge transfer complexation reaction of the drug with either iodine (I2) as a σ-acceptor (method A) in dichloromethane or picric acid (PA) as a π-acceptor (method B) in ch...