نتایج جستجو برای: Sphingosine-1-phosphate

تعداد نتایج: 2821340  

Journal: :Indian Journal of Pharmaceutical Sciences 2022

To investigate the effects and mechanism of sphingosine-1-phosphate/sphingosine-1-phosphate receptor on pro-angiogenesis in human colon cancer cells is main objective. The sphingosine-1-phosphate HT-29 SW480 were assessed by tube formation assay. Quantitative real-time polymerase chain reaction was used to detect expression interleukin-8, interleukin-6 vascular endothelial growth factor HT29 af...

Journal: :The Journal of biological chemistry 1992
N N Desai H Zhang A Olivera M E Mattie S Spiegel

Sphingosine and sphingosine-1-phosphate, metabolites of membrane sphingolipids, have recently been shown to stimulate release of calcium from internal sources and to increase proliferation of quiescent Swiss 3T3 fibroblasts (Zhang, H., Desai, N. N., Olivera, A., Seki, T., Brooker, G., and Spiegel, S. (1991) J. Cell Biol. 114, 155-167). The present study demonstrates that mitogenic concentration...

Journal: :The Journal of Cell Biology 1991
H Zhang N N Desai A Olivera T Seki G Brooker S Spiegel

Sphingosine, a metabolite of membrane sphingolipids, regulates proliferation of quiescent Swiss 3T3 fibroblasts (Zhang, H., N. E. Buckley, K. Gibson. and S. Spiegel. 1990. J. Biol. Chem. 265:76-81). The present study provides new insights into the formation and function of a unique phospholipid, a metabolite of sphingosine, which was unequivocally identified as sphingosine-1-phosphate. The rapi...

2011
Reza Soleimani Elke Heytens Kutluk Oktay

Ovarian transplantation is one of the key approaches to restoring fertility in women who became menopausal as a result of cancer treatments. A major limitation of human ovarian transplants is massive follicular loss during revascularization. Here we investigated whether sphingosine-1-phosphate or its receptor agonists could enhance neoangiogenesis and follicle survival in ovarian transplants in...

Journal: :The Journal of biological chemistry 2003
Jane Mendel Karie Heinecke Henrik Fyrst Julie D Saba

Sphingolipids are ubiquitous membrane constituents whose metabolites function as signaling molecules in eukaryotic cells. Sphingosine 1-phosphate, a key sphingolipid second messenger, regulates proliferation, motility, invasiveness, and programmed cell death. These effects of sphingosine 1-phosphate and similar phosphorylated sphingoid bases have been observed in organisms as diverse as yeast a...

Journal: :Development 2001
G Li C Foote S Alexander H Alexander

Sphingosine-1-phosphate, a product of sphingomyelin degradation, is an important element of signal transduction pathways that regulate cell proliferation and cell death. We have demonstrated additional roles for sphingosine-1-phosphate in growth and multicellular development. The specific disruption in Dictyostelium discoideum of the sphingosine-1-phosphate lyase gene, which encodes the enzyme ...

Journal: :Biochimica et Biophysica Acta (BBA) - Biomembranes 2006

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