This study was designed to determine the effect of ethanol root extract of Sphenocentrum jollyanum on Liver function Indices in Plasmodium berghei-infected mice. Liver function Indices were determined using standard methods. A total of 36 albino mice were used for the study. They were acclimatized for one week and then randomly assigned into 6 groups of A-F with 6 mice in each group. Mice in gr...

Sphenocentrum jollyanum Pierre is a member of a diverse family of plants known as Menispermaceae. They are famous for a plethora of important biological functions. S. jollyanum is a shrub native to the tropical forest zones of West Africa and thrives in deep shade. It is widely cultivated in Cameroun, Sierra Leone, Nigeria, Ghana, and Côte d'Ivoire. S. jollyanum is employed in folk medicine as ...

This study was carried out to assess the antimicrobial activities of Sphenocentrum jollyanum and Mangifera indica extract on Salmonella typhi. The antimicrobial activities of these plant extract <50% ethanol was tested against Salmonella typhi mostly belongs to pathogenic bacteria, by agar well diffusion method. The crude extracts showed a broad extract spectrum of an antibacterial activity inh...

The anti-hyperglycaemic activity of Sphenocentrum jollyanum (SJ) Pierre (Menispermaceae) was evaluated on alloxan-induced diabetic rabbits. The single extract dose in an oral tolerance test enhanced clearance of plasma glucose with decrease in the area under OGTT curve by 26.9% (P<0.05) compared to the untreated. In the alloxan-induced hyperglycaemic rabbits, the extract exerted significant blo...

The methanol extracts of Sphenocentrum Jollyanum organs were assessed for their anti-oxidant and anti-angiogenic activities using DPPH and CAM assays respectively. The results indicated the stem bark as the most active organ with an IC50 of 1.80 ± 0.25 and 1.00 ± 0.20 score (at 500 μg/pellet) on DDPH and anti-angiogenesis assays respectively. Further fractionation of the stem bark revealed the ...

Anti-inflammatory potential of the ethanol leaf extract Sphenocentrum jollyanum (ELESJ) was assessed in-vivo in mice by using carrageenan-induced paw oedema, egg albumin-induced and xylene-induced ear oedema model at doses 474.34, 948.68, 1423.03 mg/kgbw respectively. A total seventy-five matured both sexes weighing between 20 g 24 (divided into three groups 25 each for 3 different studies) wer...